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    Map7d3 MAP7 domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map7d3provided by RGD
    Official Full Name
    MAP7 domain containing 3provided by RGD
    Primary source
    RGD:1565514
    See related
    EnsemblRapid:ENSRNOG00000027831 AllianceGenome:RGD:1565514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565514
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule polymerization. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAP7D3 (MAP7 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 28.9), Lung (RPKM 21.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map7d3 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (139656587..139723239, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (134619227..134647525, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (159176825..159207167, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene four and a half LIM domains 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene bombesin receptor subtype 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. Yadav S, et al. PLoS One, 2014. PMID 24927501, Free PMC Article
    2. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. Sun X, et al. Cell Cycle, 2011 Nov 15. PMID 22142902
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP7 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271327.1 → NP_001258256.1  MAP7 domain-containing protein 3

      See identical proteins and their annotated locations for NP_001258256.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6A1Q2, A6KSP8, M0RCJ5
      Related
      ENSRNOP00000084318.2, ENSRNOT00000093766.2
      Conserved Domains (2) summary
      pfam05672
      Location:545 → 662
      MAP7; MAP7 (E-MAP-115) family
      pfam11208
      Location:62 → 136
      DUF2992; Protein of unknown function (DUF2992)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      139656587..139723239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280108.1 → XP_063136178.1  MAP7 domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      D4A0X5, M0RCJ5
      Related
      ENSRNOP00000038744.7, ENSRNOT00000030445.8

    2. XM_063280106.1 → XP_063136176.1  MAP7 domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      M0RCJ5

    3. XM_039099852.2 → XP_038955780.1  MAP7 domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      M0RCJ5
      Conserved Domains (3) summary
      PTZ00121
      Location:80 → 251
      PTZ00121; MAEBL; Provisional
      PRK09510
      Location:116 → 195
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      pfam05672
      Location:601 → 733
      MAP7; MAP7 (E-MAP-115) family

    4. XM_039099853.2 → XP_038955781.1  MAP7 domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      M0RCJ5
      Conserved Domains (3) summary
      PTZ00121
      Location:80 → 251
      PTZ00121; MAEBL; Provisional
      PRK09510
      Location:116 → 195
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      pfam05672
      Location:601 → 718
      MAP7; MAP7 (E-MAP-115) family

    5. XM_017602097.3 → XP_017457586.1  MAP7 domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      M0RCJ5
      Related
      ENSRNOP00000099362.1, ENSRNOT00000139454.1

    6. XM_063280105.1 → XP_063136175.1  MAP7 domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      M0RCJ5

    7. XM_039099854.2 → XP_038955782.1  MAP7 domain-containing protein 3 isoform X7

      Conserved Domains (3) summary
      PTZ00121
      Location:80 → 251
      PTZ00121; MAEBL; Provisional
      PRK09510
      Location:116 → 195
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      pfam05672
      Location:601 → 736
      MAP7; MAP7 (E-MAP-115) family

    RNA

    1. XR_005497999.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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