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    Zfp420 zinc finger protein 420 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 103690163, updated on 9-Dec-2024

    Summary

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    Symbol
    Zfp420provided by RGD
    Full Name
    zinc finger protein 420provided by RGD
    Primary source
    RGD:2323829
    See related
    EnsemblRapid:ENSRNOG00000020774 AllianceGenome:RGD:2323829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be active in nucleus. Orthologous to several human genes including ZNF420 (zinc finger protein 420). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 47.7), Brain (RPKM 46.9) and 9 other tissues See more
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    Genomic context

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    See Zfp420 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94259715..94271102)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85092810..85143682)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88204836..88216548)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 420 Neighboring gene zinc finger protein 27 Neighboring gene zinc finger protein 74 Neighboring gene uncharacterized LOC103691076

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation by p53. Beckerman R, et al. Cold Spring Harb Perspect Biol, 2010 Aug. PMID 20679336, Free PMC Article
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 383; zinc finger protein 420
    Names
    Zinc finger protein 420-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432916.1 → NP_001419845.1  zinc finger protein 420 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NM_001432917.1 → NP_001419846.1  zinc finger protein 420 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      M0R494

    3. NM_001432918.1 → NP_001419847.1  zinc finger protein 420 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001432919.1 → NP_001419848.1  zinc finger protein 420 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    5. NM_001432920.1 → NP_001419849.1  zinc finger protein 420 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94259715..94271102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093741.2 → XP_038949669.1  zinc finger protein 383 isoform X1

      UniProtKB/TrEMBL
      M0R5R2
      Related
      ENSRNOP00000064174.4, ENSRNOT00000072556.4
      Conserved Domains (5) summary
      smart00349
      Location:66 → 127
      KRAB; krueppel associated box
      COG5048
      Location:285 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224 → 246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:266 → 291
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006228747.5 → XP_006228809.1  zinc finger protein 383 isoform X2

      See identical proteins and their annotated locations for XP_006228809.1

      UniProtKB/TrEMBL
      M0R5R2
      Related
      ENSRNOP00000064739.4, ENSRNOT00000074580.4
      Conserved Domains (6) summary
      smart00349
      Location:66 → 126
      KRAB; krueppel associated box
      COG5048
      Location:284 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:475 → 497
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:66 → 105
      KRAB; KRAB box
      pfam13465
      Location:378 → 402
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039093752.2 → XP_038949680.1  zinc finger protein 383 isoform X7

      Conserved Domains (4) summary
      smart00349
      Location:12 → 73
      KRAB; krueppel associated box
      COG5048
      Location:231 → 475
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:312 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:212 → 237
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039093746.2 → XP_038949674.1  zinc finger protein 383 isoform X5

      Conserved Domains (4) summary
      smart00349
      Location:27 → 88
      KRAB; krueppel associated box
      COG5048
      Location:246 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:227 → 252
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006228749.5 → XP_006228811.1  zinc finger protein 383 isoform X6

      Conserved Domains (6) summary
      smart00349
      Location:27 → 87
      KRAB; krueppel associated box
      COG5048
      Location:245 → 489
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326 → 346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:436 → 458
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:27 → 66
      KRAB; KRAB box
      pfam13465
      Location:339 → 363
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039093743.2 → XP_038949671.1  zinc finger protein 383 isoform X3

      Conserved Domains (4) summary
      smart00349
      Location:35 → 96
      KRAB; krueppel associated box
      COG5048
      Location:254 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335 → 355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:235 → 260
      zf-H2C2_2; Zinc-finger double domain

    7. XM_039093751.2 → XP_038949679.1  zinc finger protein 383 isoform X7

      Conserved Domains (4) summary
      smart00349
      Location:12 → 73
      KRAB; krueppel associated box
      COG5048
      Location:231 → 475
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:312 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:212 → 237
      zf-H2C2_2; Zinc-finger double domain

    8. XM_063277766.1 → XP_063133836.1  zinc finger protein 383 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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