Atp6v1b1 ATPase H+ transporting V1 subunit B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v1b1provided by RGD
Official Full Name: ATPase H+ transporting V1 subunit B1provided by RGD
Primary source: RGD:1310619
See related: EnsemblRapid:ENSRNOG00000013573 AllianceGenome:RGD:1310619
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in several processes, including regulation of pH; synaptic vesicle lumen acidification; and vacuolar proton-transporting V-type ATPase complex assembly. Predicted to act upstream of or within several processes, including renal sodium excretion; renal sodium ion transport; and renal water homeostasis. Located in apical plasma membrane and basolateral plasma membrane. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 158.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117781444..117800103)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (116223799..116242475)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (115417100..115435754)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within olfactory behavior	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in pH reduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of pH	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within renal sodium excretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in renal tubular secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar proton-transporting V-type ATPase complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
part_of vacuolar proton-transporting V-type ATPase complex	ISO Inferred from Sequence Orthology more info
part_of vacuolar proton-transporting V-type ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: V-type proton ATPase subunit B, kidney isoform

Names: ATPase, H transporting, lysosomal V1 subunit B1; ATPase, H+ transporting, V1 subunit B

NP_001101337.2

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.