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    Zfp341 zinc finger protein 341 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296300, updated on 9-Dec-2024

    Summary

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    Symbol
    Zfp341provided by RGD
    Full Name
    zinc finger protein 341provided by RGD
    Primary source
    RGD:1564726
    See related
    EnsemblRapid:ENSRNOG00000017086 AllianceGenome:RGD:1564726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp966; Znf341; LRRGT00145; AABR07054367.1
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in hyper IgE recurrent infection syndrome 3. Orthologous to human ZNF341 (zinc finger protein 341). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 25.2), Lung (RPKM 22.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp341 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163582937..163616448)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143122699..143156250)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150114853..150172425)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene peroxisomal membrane protein 4 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 3 Neighboring gene transfer RNA alanine (anticodon AGC) 3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 like 2 Neighboring gene charged multivesicular body protein 4B Neighboring gene uncharacterized LOC134486467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNF341 controls STAT3 expression and thereby immunocompetence. Frey-Jakobs S, et al. Sci Immunol, 2018 Jun 15. PMID 29907690, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 341
    Names
    zinc finger protein 966

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430392.1 → NP_001417321.1  zinc finger protein 341 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KI01, F7ETL6

    2. NM_001430393.1 → NP_001417322.1  zinc finger protein 341 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KI01

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      163582937..163616448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762405.4 → XP_008760627.2  zinc finger protein 341 isoform X1

      Related
      ENSRNOP00000043308.4, ENSRNOT00000047286.5
      Conserved Domains (3) summary
      COG5048
      Location:321 → 726
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:565 → 585
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:539 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039106691.2 → XP_038962619.1  zinc finger protein 341 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:314 → 719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:558 → 578
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:532 → 554
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_039106692.2 → XP_038962620.1  zinc finger protein 341 isoform X3

      UniProtKB/TrEMBL
      A6KI01
      Conserved Domains (2) summary
      COG5048
      Location:254 → 659
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_063285100.1 → XP_063141170.1  zinc finger protein 341 isoform X4

      UniProtKB/TrEMBL
      A6KI01

    5. XM_039106694.1 → XP_038962622.1  zinc finger protein 341 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:42 → 447
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047859.1: Suppressed sequence

      Description
      NM_001047859.1: This RefSeq was removed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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