Slc39a14 solute carrier family 39 member 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc39a14provided by RGD
Official Full Name: solute carrier family 39 member 14provided by RGD
Primary source: RGD:1307026
See related: EnsemblRapid:ENSRNOG00000009832 AllianceGenome:RGD:1307026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable monoatomic cation transmembrane transporter activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; negative regulation of cyclic-nucleotide phosphodiesterase activity; and transition metal ion transport. Predicted to act upstream of or within iron ion transport and zinc ion transmembrane transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and bounding membrane of organelle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 477.0), Heart (RPKM 179.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (51786517..51833260, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45376806..45423549, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (51982872..52029841, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After tissue is damaged in abdominal surgery, cytokines are released to the circulation, IL-6, the main mediator of acute phase response induces the expression of MT and Zip14, and the increase of transporter Zip14 promotes the uptake of zinc by liver at the expense of serum zinc
Title: Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.
Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats.
Title: Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
Data suggest magnesium deficiency enhances liver zinc uptake by up-regulating expression of Zip14/Slc39a14 (solute carrier family 39, member 14); increased liver content of zinc leads to up-regulation of expression of metallothioneins (Mt1 and Mt2).
Title: Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadmium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ferrous iron transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion:monoatomic cation symporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in cadmium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in manganese ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of hormone levels	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal cation symporter ZIP14

Names: solute carrier family 39 (zinc transporter), member 14; zinc transporter ZIP14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107275.1 → NP_001100745.1 metal cation symporter ZIP14 precursor

See identical proteins and their annotated locations for NP_001100745.1

Status: PROVISIONAL

Source sequence(s)

CH473951

UniProtKB/TrEMBL

A6HTK2, D3ZZM0

Related

ENSRNOP00000013066.2, ENSRNOT00000013067.5

Conserved Domains (1) summary

pfam02535
Location:150 → 481

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

51786517..51833260 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252270.4 → XP_006252332.1 metal cation symporter ZIP14 isoform X1

UniProtKB/TrEMBL

A0A8I6ABU1

Related

ENSRNOP00000091533.1, ENSRNOT00000105917.2

Conserved Domains (1) summary

pfam02535
Location:151 → 481

Zip; ZIP Zinc transporter
XM_039093346.2 → XP_038949274.1 metal cation symporter ZIP14 isoform X1

UniProtKB/TrEMBL

A0A8I6ABU1

Conserved Domains (1) summary

pfam02535
Location:151 → 481

Zip; ZIP Zinc transporter
XM_039093343.2 → XP_038949271.1 metal cation symporter ZIP14 isoform X1

UniProtKB/TrEMBL

A0A8I6ABU1

Conserved Domains (1) summary

pfam02535
Location:151 → 481

Zip; ZIP Zinc transporter
XM_063274299.1 → XP_063130369.1 metal cation symporter ZIP14 isoform X1

UniProtKB/TrEMBL

A0A8I6ABU1
XM_039093347.2 → XP_038949275.1 metal cation symporter ZIP14 isoform X1

UniProtKB/TrEMBL

A0A8I6ABU1

Conserved Domains (1) summary

pfam02535
Location:151 → 481

Zip; ZIP Zinc transporter
XM_063274301.1 → XP_063130371.1 metal cation symporter ZIP14 isoform X2