Akap4 A-kinase anchoring protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap4provided by RGD
Official Full Name: A-kinase anchoring protein 4provided by RGD
Primary source: RGD:620828
See related: EnsemblRapid:ENSRNOG00000002921 AllianceGenome:RGD:620828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase A binding activity. Predicted to be involved in flagellated sperm motility and protein localization. Predicted to act upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; establishment of protein localization; and sperm flagellum assembly. Predicted to be located in several cellular components, including Z disc; sperm flagellum; and sperm head-tail coupling apparatus. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 819.9) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (18107256..18117549, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (15435391..15445684, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (16296027..16306078, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in sperm flagellum assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm flagellum assembly	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in sperm end piece	IEA Inferred from Electronic Annotation more info
located_in sperm end piece	ISO Inferred from Sequence Orthology more info
is_active_in sperm fibrous sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm fibrous sheath	IEA Inferred from Electronic Annotation more info
is_active_in sperm fibrous sheath	ISO Inferred from Sequence Orthology more info
located_in sperm fibrous sheath	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm head-tail coupling apparatus	IEA Inferred from Electronic Annotation more info
located_in sperm head-tail coupling apparatus	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IEA Inferred from Electronic Annotation more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 4

Names: 75 kDa fibrous sheath protein; A kinase (PRKA) anchor protein 4; AKAP-4; PRKA4; major sperm fibrous sheath protein; protein kinase A-anchoring protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431627.1 → NP_001418556.1 A-kinase anchor protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_024402.2 → NP_077378.2 A-kinase anchor protein 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6KPB5, F1LMR8

Related

ENSRNOP00000003939.7, ENSRNOT00000003939.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

18107256..18117549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100088.2 → XP_038956016.1 A-kinase anchor protein 4 isoform X1

Related

ENSRNOP00000088271.1, ENSRNOT00000102856.2

Conserved Domains (1) summary

smart00807
Location:5 → 838

AKAP_110; A-kinase anchor protein 110 kDa