Lgi1 leucine-rich, glioma inactivated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgi1provided by RGD
Official Full Name: leucine-rich, glioma inactivated 1provided by RGD
Primary source: RGD:628742
See related: EnsemblRapid:ENSRNOG00000014758 AllianceGenome:RGD:628742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Involved in positive regulation of synaptic transmission. Located in axon initial segment; dendrite; and extracellular space. Used to study epilepsy and epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 248.7), Muscle (RPKM 30.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (245455691..245497036)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (236043269..236084617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256955944..256996835)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission.
Title: Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission.
TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1.
Title: TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1.
ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.
Title: ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.
he down-regulation of Kir4.1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation.
Title: Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
These results of this study suggest that Lgi1(L385R/+) rats are useful as an animal model of human autosomal dominant lateral temporal lobe epilepsy.
Title: Evaluation of seizure foci and genes in the Lgi1(L385R/+) mutant rat.
The expression of LOTUS, LGI1, and ADAM22 in hippocampal subregions dissected from mature adult and aged rats cognitively phenotyped for spatial learning and memory by Morris water maze testing, was quantified.
Title: Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
LGI1 epilepsy-causing missense mutations might cause a depletion of the protein in neurons, and not only a failure of Lgi1 secretion.
Title: A rat model for LGI1-related epilepsies.
The Lgi1 is a cytoplasmic protein distributed both in the soma and in the processes of neurons.
Title: Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons.
ADAM22, a transmembrane protein that when mutated causes seizure, serves as a receptor for LGI1; LGI1 enhances AMPA receptor-mediated synaptic transmission in hippocampal slices; mutated form of LGI1 fails to bind to ADAM22
Title: Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T15408 (e-PCR)
- UniSTS:27715

Lgi1 (e-PCR), detects polymorphism
- UniSTS:534868

BQ202124 (e-PCR)
- UniSTS:260700

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich glioma-inactivated protein 1

Names: leucine-rich glioma-inactivated protein 1-like; leucine-rich repeat LGI family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145769.4 → NP_665712.1 leucine-rich glioma-inactivated protein 1 precursor

See identical proteins and their annotated locations for NP_665712.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5FWS7, Q8K4Y5

UniProtKB/TrEMBL

A0A8L2QA98, A6I186

Related

ENSRNOP00000078389.1, ENSRNOT00000113976.2

Conserved Domains (4) summary

TIGR00864
Location:146 → 221

PCC; polycystin cation channel protein

sd00031
Location:71 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam03736
Location:510 → 549

EPTP; EPTP domain

pfam13855
Location:91 → 151

LRR_8; Leucine rich repeat