Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ikbkeprovided by RGD
Official Full Name: inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by RGD
Primary source: RGD:1308352
See related: EnsemblRapid:ENSRNOG00000025100 AllianceGenome:RGD:1308352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of gene expression; and positive regulation of innate immune response. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 144.4), Spleen (RPKM 100.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45264404..45290737, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42712154..42738470, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48031325..48056394, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IKKepsilon protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Title: IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.
Long non-coding RNA CYTOR modulates pathological cardiac hypertrophy through miR-155-mediated IKBKE signaling.
Title: Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables IkappaB kinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
NOT enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit epsilon

Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon

NP_001102324.1

EC 2.7.11.10

XP_017454364.1

EC 2.7.11.10

XP_038946877.1

EC 2.7.11.10

XP_038946878.1

EC 2.7.11.10

XP_063128583.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108854.1 → NP_001102324.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon

See identical proteins and their annotated locations for NP_001102324.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

A6IC17, D4A5E7

Related

ENSRNOP00000112135.1, ENSRNOT00000151581.1

Conserved Domains (4) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 648

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain

cl41735
Location:670 → 715

TBK1_IKKE-like_C; C-terminal domain of non-canonical Inhibitor of kappa B kinases, IKK-E and TBK1, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45264404..45290737 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090949.2 → XP_038946877.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 648

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_017598875.3 → XP_017454364.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1

Related

ENSRNOP00000100304.1, ENSRNOT00000151006.1

Conserved Domains (3) summary

cd17128
Location:308 → 383

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:402 → 648

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:15 → 330

PKc_like; Protein Kinases, catalytic domain
XM_039090950.2 → XP_038946878.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3

Conserved Domains (3) summary

cd17128
Location:88 → 163

Ubl_IKKE; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKK-E)

pfam18394
Location:182 → 428

TBK1_CCD1; TANK-binding kinase 1 coiled-coil domain 1

cl21453
Location:11 → 110

PKc_like; Protein Kinases, catalytic domain
XM_063272513.1 → XP_063128583.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2