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    Hars2 histidyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hars2provided by RGD
    Official Full Name
    histidyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1308426
    See related
    EnsemblRapid:ENSRNOG00000016087 AllianceGenome:RGD:1308426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zmat2; Hars2l; RGD1308426
    Summary
    Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in histidyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 147.1), Adrenal (RPKM 98.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hars2 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28672810..28682367)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28398790..28408075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29629203..29638460)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA72 Neighboring gene WD repeat domain 55 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene protocadherin alpha 4 Neighboring gene zinc finger, matrin type 2 Neighboring gene zinc finger protein 260, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Pierce SB, et al. Proc Natl Acad Sci U S A, 2011 Apr 19. PMID 21464306, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109366

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in histidyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histidyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable histidine--tRNA ligase, mitochondrial
    Names
    histidyl-tRNA synthetase 2, mitochondrial (putative)
    zinc finger, matrin type 2
    NP_001014034.2
    XP_006254637.1
    XP_038952791.1
    XP_038952792.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014012.2 → NP_001014034.2  probable histidine--tRNA ligase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BC089973, CK481952, CV075096
      UniProtKB/TrEMBL
      A6J338, F1M9C9
      Related
      ENSRNOP00000021797.3, ENSRNOT00000021797.7
      Conserved Domains (3) summary
      COG0124
      Location:58 → 505
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:71 → 396
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:410 → 501
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28672810..28682367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254575.5 → XP_006254637.1  probable histidine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM00, A6J338
      Related
      ENSRNOP00000078926.1, ENSRNOT00000095646.2
      Conserved Domains (2) summary
      cd00773
      Location:63 → 356
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:370 → 461
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    2. XM_039096864.2 → XP_038952792.1  probable histidine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN02972
      Location:15 → 343
      PLN02972; Histidyl-tRNA synthetase

    3. XM_039096863.2 → XP_038952791.1  probable histidine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN02972
      Location:15 → 343
      PLN02972; Histidyl-tRNA synthetase

    RNA

    1. XR_005496038.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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