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    Hsf5 heat shock transcription factor family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 327992, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hsf5provided by MGI
    Official Full Name
    heat shock transcription factor family member 5provided by MGI
    Primary source
    MGI:MGI:2685585
    See related
    Ensembl:ENSMUSG00000070345 AllianceGenome:MGI:2685585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm739; MLZ-220
    Summary
    Enables DNA-binding transcription activator activity and DNA-binding transcription repressor activity. Involved in male meiotic nuclear division and spermatogenesis. Located in XY body and nucleus. Orthologous to human HSF5 (heat shock transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 32.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hsf5 in Genome Data Viewer
    Location:
    11 C; 11 52.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87507225..87550715)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87616399..87659875)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene septin 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87405102-87405211 Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E5260 Neighboring gene STARR-seq mESC enhancer starr_30296 Neighboring gene ring finger protein 43 Neighboring gene RIKEN cDNA 1110028F11 gene Neighboring gene predicted gene, 25968

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock factor protein 5
    Names
    HSF 5
    HSTF 5
    heat shock transcription factor 5
    protein expressed in male leptotene and zygotene spermatocytes 220

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045527.1NP_001038992.1  heat shock factor protein 5

      See identical proteins and their annotated locations for NP_001038992.1

      Status: VALIDATED

      Source sequence(s)
      AK166561, AL596086, BX639497
      Consensus CDS
      CCDS36269.1
      UniProtKB/Swiss-Prot
      B2KGG8, Q3TLD8, Q5ND04
      Related
      ENSMUSP00000091488.4, ENSMUST00000093956.4
      Conserved Domains (1) summary
      pfam00447
      Location:15152
      HSF_DNA-bind; HSF-type DNA-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87507225..87550715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_879708.4 RNA Sequence

    2. XR_004936980.1 RNA Sequence