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    Rbm24 RNA binding motif protein 24 [ Mus musculus (house mouse) ]

    Gene ID: 666794, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbm24provided by MGI
    Official Full Name
    RNA binding motif protein 24provided by MGI
    Primary source
    MGI:MGI:3610364
    See related
    Ensembl:ENSMUSG00000038132 AllianceGenome:MGI:3610364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330546B05Rik
    Summary
    Enables mRNA 3'-UTR binding activity and pre-mRNA intronic binding activity. Involved in endocardial cushion development; positive regulation of skeletal muscle fiber differentiation; and regulation of mRNA metabolic process. Located in cytoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb bud; musculature; and sensory organ. Used to study dilated cardiomyopathy. Orthologous to human RBM24 (RNA binding motif protein 24). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 43.8), bladder adult (RPKM 10.5) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Rbm24 in Genome Data Viewer
    Location:
    13 A5; 13 23.61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (46571664..46584575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (46418102..46431099)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34407 Neighboring gene predicted gene, 45949 Neighboring gene STARR-seq mESC enhancer starr_34408 Neighboring gene stathmin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_34412 Neighboring gene predicted gene, 35110 Neighboring gene STARR-seq mESC enhancer starr_34413 Neighboring gene STARR-seq mESC enhancer starr_34414 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 Neighboring gene VISTA enhancer mm132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46712127-46712352 Neighboring gene STARR-seq mESC enhancer starr_34416 Neighboring gene family with sequence similarity 8, member A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA CDS binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 3'-UTR-mediated mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myotube differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of skeletal muscle fiber differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081425.1NP_001074894.1  RNA-binding protein 24

      See identical proteins and their annotated locations for NP_001074894.1

      Status: PROVISIONAL

      Source sequence(s)
      AC124411
      Consensus CDS
      CCDS36651.1
      UniProtKB/Swiss-Prot
      D3Z4I3
      Related
      ENSMUSP00000043120.4, ENSMUST00000037923.5
      Conserved Domains (1) summary
      cd12384
      Location:1186
      RRM_RBM24_RBM38_like; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      46571664..46584575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_382235.4 RNA Sequence