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    Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 [ Mus musculus (house mouse) ]

    Gene ID: 14375, updated on 3-Dec-2024

    Summary

    Official Symbol
    Xrcc6provided by MGI
    Official Full Name
    X-ray repair complementing defective repair in Chinese hamster cells 6provided by MGI
    Primary source
    MGI:MGI:95606
    See related
    Ensembl:ENSMUSG00000022471 AllianceGenome:MGI:95606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ku70; 70kDa; G22p1
    Summary
    Enables double-stranded DNA binding activity. Involved in positive regulation of lymphocyte differentiation. Acts upstream of or within DNA metabolic process; positive regulation of neurogenesis; and response to ionizing radiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and liver lobe. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.8), liver E14 (RPKM 4.4) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Xrcc6 in Genome Data Viewer
    Location:
    15 E1; 15 38.33 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81868805..81924286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81987833..82040085)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene desumoylating isopeptidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene RIKEN cDNA 4930407I10 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 5'-deoxyribose-5-phosphate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to gamma radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via classical nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via nonhomologous end joining NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in recombinational repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of DNA-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of DNA-dependent protein kinase-DNA ligase 4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of DNA-dependent protein kinase-DNA ligase 4 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Ku70:Ku80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Ku70:Ku80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Ku70:Ku80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nonhomologous end joining complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    X-ray repair cross-complementing protein 6
    Names
    5'-dRP/AP lyase Ku70
    5'-deoxyribose-5-phosphate lyase Ku70
    ATP-dependent DNA helicase 2 subunit 1
    ATP-dependent DNA helicase II 70 kDa subunit
    CTC box-binding factor 75 kDa subunit
    CTC75
    CTCBF
    DNA repair protein XRCC6
    Ku p70
    ku autoantigen protein p70 homolog
    thyroid autoantigen 70 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411249.1NP_001398178.1  X-ray repair cross-complementing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102176
      UniProtKB/Swiss-Prot
      O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
      UniProtKB/TrEMBL
      A0A0R4J187
      Related
      ENSMUSP00000097968.5, ENSMUST00000100399.11
    2. NM_001411250.1NP_001398179.1  X-ray repair cross-complementing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102176
    3. NM_010247.3NP_034377.2  X-ray repair cross-complementing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_034377.2

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Consensus CDS
      CCDS37153.1
      UniProtKB/Swiss-Prot
      O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
      UniProtKB/TrEMBL
      A0A0R4J187
      Related
      ENSMUSP00000068559.7, ENSMUST00000069530.13
      Conserved Domains (1) summary
      TIGR00578
      Location:22606
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81868805..81924286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245456.4XP_011243758.1  X-ray repair cross-complementing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011243758.1

      UniProtKB/Swiss-Prot
      O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
      UniProtKB/TrEMBL
      A0A0R4J187
      Conserved Domains (1) summary
      TIGR00578
      Location:22606
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
    2. XM_006520442.5XP_006520505.1  X-ray repair cross-complementing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006520505.1

      UniProtKB/Swiss-Prot
      O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
      UniProtKB/TrEMBL
      A0A0R4J187
      Conserved Domains (1) summary
      TIGR00578
      Location:22606
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
    3. XM_006520444.2XP_006520507.1  X-ray repair cross-complementing protein 6 isoform X2

      UniProtKB/Swiss-Prot
      O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
      Conserved Domains (1) summary
      TIGR00578
      Location:51593
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    RNA

    1. XR_383982.4 RNA Sequence