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    Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 [ Mus musculus (house mouse) ]

    Gene ID: 13105, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp2d9provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily d, polypeptide 9provided by MGI
    Primary source
    MGI:MGI:88606
    See related
    Ensembl:ENSMUSG00000068086 AllianceGenome:MGI:88606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp2d; P450-2D
    Summary
    Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 87.9), liver E18 (RPKM 37.3) and 2 other tissues See more
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    Genomic context

    See Cyp2d9 in Genome Data Viewer
    Location:
    15 E1; 15 38.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82336578..82341028)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82452377..82456827)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19267 Neighboring gene predicted gene, 46501 Neighboring gene STARR-seq mESC enhancer starr_39295 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 32, pseudogene Neighboring gene STARR-seq mESC enhancer starr_39296 Neighboring gene predicted gene, 27825

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 2D9
    Names
    CYPIID9
    cytochrome P450, 2d9
    cytochrome P450-16-alpha
    cytochrome P450CA
    testosterone 16-alpha hydroxylase
    testosterone 16alpha-hydroxylase
    NP_034136.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010006.2NP_034136.2  cytochrome P450 2D9

      See identical proteins and their annotated locations for NP_034136.2

      Status: VALIDATED

      Source sequence(s)
      AK143963, M23998
      Consensus CDS
      CCDS27691.1
      UniProtKB/Swiss-Prot
      P11714, Q64489, Q921V1
      UniProtKB/TrEMBL
      Q3UNW2
      Related
      ENSMUSP00000086530.6, ENSMUST00000089129.7
      Conserved Domains (1) summary
      pfam00067
      Location:37496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82336578..82341028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)