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    VAMP2 vesicle associated membrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 6844, updated on 4-Jan-2025

    Summary

    Official Symbol
    VAMP2provided by HGNC
    Official Full Name
    vesicle associated membrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12643
    See related
    Ensembl:ENSG00000220205 MIM:185881; AllianceGenome:HGNC:12643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYB2; VAMP-2; NEDHAHM
    Summary
    The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues See more
    Orthologs
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    Genomic context

    See VAMP2 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8159147..8162948, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8064587..8068400, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8062465..8066266, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8043207-8043885 Neighboring gene tRNA-Thr (anticodon AGT) 5-1 Neighboring gene period circadian regulator 1 Neighboring gene microRNA 6883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8053229-8053876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8163 Neighboring gene Sharpr-MPRA regulatory region 8148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8057595-8058375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11672 Neighboring gene uncharacterized LOC105371520 Neighboring gene transmembrane protein 107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11673 Neighboring gene small nucleolar RNA, C/D box 118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8079237-8079848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8079849-8080460

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ11460

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNARE binding  
    enables calcium-dependent protein binding  
    enables calmodulin binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables syntaxin binding PubMed 
    enables syntaxin binding  
    enables syntaxin-1 binding  
    enables syntaxin-1 binding  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport  
    involved_in SNARE complex assembly  
    involved_in calcium-ion regulated exocytosis  
    involved_in cellular response to insulin stimulus  
    involved_in eosinophil degranulation PubMed 
    involved_in exocytosis PubMed 
    involved_in long-term synaptic potentiation  
    involved_in membrane fusion  
    NOT involved_in mucus secretion PubMed 
    NOT involved_in natural killer cell degranulation PubMed 
    NOT involved_in neutrophil degranulation PubMed 
    involved_in positive regulation of intracellular protein transport  
    involved_in protein transport  
    involved_in protein-containing complex assembly  
    involved_in regulation of delayed rectifier potassium channel activity  
    involved_in regulation of exocytosis  
    NOT involved_in regulation of histamine secretion by mast cell PubMed 
    involved_in regulation of vesicle-mediated transport  
    involved_in response to glucose  
    involved_in synaptic vesicle endocytosis  
    involved_in synaptic vesicle exocytosis  
    involved_in synaptic vesicle exocytosis PubMed 
    involved_in vesicle fusion  
    involved_in vesicle fusion PubMed 
    involved_in vesicle-mediated transport  
    Items 1 - 20 of 33
    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    part_of SNARE complex PubMed 
    located_in clathrin-coated endocytic vesicle membrane  
    located_in clathrin-coated vesicle PubMed 
    located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  
    located_in clathrin-sculpted glutamate transport vesicle membrane  
    located_in clathrin-sculpted monoamine transport vesicle membrane  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in membrane PubMed 
    located_in neuron projection  
    located_in neuron projection terminus  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in secretory granule  
    NOT located_in secretory granule membrane PubMed 
    located_in secretory granule membrane  
    located_in synapse  
    located_in synaptic vesicle  
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  
    located_in trans-Golgi network  
    located_in vesicle PubMed 
    part_of voltage-gated potassium channel complex  
    located_in zymogen granule membrane  
    Items 1 - 20 of 33

    General protein information

    Preferred Names
    vesicle-associated membrane protein 2
    Names
    synaptobrevin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330125.1 → NP_001317054.1  vesicle-associated membrane protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC129492, BU625107
      Consensus CDS
      CCDS82064.1
      UniProtKB/TrEMBL
      F8WCA0, J3QRU4
      Related
      ENSP00000418572.1, ENST00000488857.5
      Conserved Domains (1) summary
      cd15870
      Location:32 → 94
      R-SNARE_VAMP2; SNARE motif of VAMP2
    2. NM_014232.3 → NP_055047.2  vesicle-associated membrane protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055047.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC129492, AK021522, AK225777, BU625107
      Consensus CDS
      CCDS32561.1
      UniProtKB/Swiss-Prot
      P19065, P63027, Q9BUC2
      UniProtKB/TrEMBL
      J3QRU4
      Related
      ENSP00000314214.6, ENST00000316509.11
      Conserved Domains (1) summary
      cd15870
      Location:30 → 92
      R-SNARE_VAMP2; SNARE motif of VAMP2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8159147..8162948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8064587..8068400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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