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    GLIPR1L1 GLIPR1 like 1 [ Homo sapiens (human) ]

    Gene ID: 256710, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GLIPR1L1provided by HGNC
    Official Full Name
    GLIPR1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28392
    See related
    Ensembl:ENSG00000173401 MIM:610395; AllianceGenome:HGNC:28392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO7434; ALKN2972
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and protein localization involved in acrosome reaction. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal vesicle and sperm head-tail coupling apparatus. Predicted to be part of protein complex involved in cell-cell adhesion. Predicted to be active in extracellular space and outer acrosomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 4.4) and fat (RPKM 0.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See GLIPR1L1 in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75334670..75370560)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75309262..75345149)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75728450..75764340)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CAPS2 antisense RNA 1 Neighboring gene cyclin G2 pseudogene 1 Neighboring gene calcyphosine 2 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75734995-75735496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75735497-75735996 Neighboring gene uncharacterized LOC124902968 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene GLIPR1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene GLI pathogenesis related 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Gibbs GM, et al. Endocrinology, 2010 May. PMID 20219979
    2. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Ren C, et al. Genomics, 2006 Aug. PMID 16714093
    3. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article
    5. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of GLI pathogenesis-related 1 like 1 (GLIPR1L1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

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    Homology

    Clone Names

    • MGC26856

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein complex involved in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLIPR1-like protein 1
    Names
    GLI pathogenesis related 1 like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304964.2 → NP_001291893.1  GLIPR1-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001291893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121761, AY358731, BC014603, BG196035
      Consensus CDS
      CCDS76578.1
      UniProtKB/Swiss-Prot
      Q6UWM5, Q96L06
      Related
      ENSP00000367967.4, ENST00000378695.9
      Conserved Domains (1) summary
      cd05385
      Location:32 → 174
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    2. NM_152779.4 → NP_689992.1  GLIPR1-like protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_689992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC121761, AY358731, BC014603, BG196035
      Consensus CDS
      CCDS9009.1
      UniProtKB/Swiss-Prot
      Q6UWM5
      Related
      ENSP00000310770.2, ENST00000312442.2
      Conserved Domains (1) summary
      cd05385
      Location:32 → 174
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75334670..75370560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538134.4 → XP_011536436.3  GLIPR1-like protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75309262..75345149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371684.1 → XP_054227659.1  GLIPR1-like protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWM5.2 GenPept UniProtKB/Swiss-Prot:Q6UWM5

    Gene LinkOut

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