Lsp1 lymphocyte-specific protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lsp1provided by RGD
Official Full Name: lymphocyte-specific protein 1provided by RGD
Primary source: RGD:1306133
See related: EnsemblRapid:ENSRNOG00000020300 AllianceGenome:RGD:1306133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within cellular response to interleukin-7; chemotaxis; and defense response. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human LSP1 (lymphocyte specific protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 323.0), Thymus (RPKM 309.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207044157..207077891)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197614677..197648414)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (215628750..215662505)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

functions as a negative regulator of proliferation and migration in hepatoma
Title: Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137141 (e-PCR)
- UniSTS:219229

RH140919 (e-PCR)
- UniSTS:222933

RH132742 (e-PCR)
- UniSTS:216025

M90316 (e-PCR)
- UniSTS:159725

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte-specific protein 1

Names: 1 BAC CH230-300K22 (Children's Hospital Oakland Research Institute) complete; lymphocyte specific 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415989.1 → NP_001402918.1 lymphocyte-specific protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GLM4, Q4QQV6

Related

ENSRNOP00000086060.2, ENSRNOT00000094065.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

207044157..207077891

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025420.1: Suppressed sequence

Description

NM_001025420.1: This RefSeq was removed because currently there is insufficient support for the transcript.