Ppp1r14d protein phosphatase 1, regulatory (inhibitor) subunit 14D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r14dprovided by RGD
Official Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 14Dprovided by RGD
Primary source: RGD:628891
See related: EnsemblRapid:ENSRNOG00000012648 AllianceGenome:RGD:628891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gbpi
Summary: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be located in cytoplasm and membrane. Orthologous to human PPP1R14D (protein phosphatase 1 regulatory inhibitor subunit 14D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 20.9), Thymus (RPKM 8.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126658886..126673132, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106205043..106219290, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111022920..111037166, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain PPP1R14D is upregulated in alloxan diabetes. It inhibits the function of PP1, switches-on glycogen breakdown and switches-off glycogen synthesis due to lack of insulin.
Title: Characterization of the brain proteome of rats with diabetes mellitus through two-dimensional electrophoresis and mass spectrometry.
PP-1 activity due to a decrease in cyclic GMP-PKG modulation plays a role for the age-related reduction of alpha(2/3)-Na,K-ATPase activity in rat cerebellum.
Title: Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity.
A gastrointestinal- and brain-specific PP1 inhibitory protein (GBPI-1)is activated by PKC phosphorylation. A longer GBPI-2 splice variant mRNA is found in testis.
Title: GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 14D

Names: GBPI-1; gastrointestinal and brain-specific PP1-inhibitory protein 1; gastrointestinal- and brain-specific PKC-activated PP1 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.