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    Nmi N-myc (and STAT) interactor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmiprovided by RGD
    Official Full Name
    N-myc (and STAT) interactorprovided by RGD
    Primary source
    RGD:1311721
    See related
    EnsemblRapid:ENSRNOG00000027502 AllianceGenome:RGD:1311721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Predicted to be located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 288.2), Thymus (RPKM 244.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmi in Genome Data Viewer
    Location:
    3q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (56824778..56848891, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (36415607..36439716, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (37458891..37480984, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28, pseudogene 9 Neighboring gene RNA binding motif protein 43 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta), pseudogene 2 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta), pseudogene 3 Neighboring gene lactate dehydrogenase A, pseudogene 11 Neighboring gene TNF alpha induced protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. Brozzi F, et al. J Biol Chem, 2014 Jul 25. PMID 24936061, Free PMC Article
    2. Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. Wang J, et al. J Immunol, 2013 Sep 15. PMID 23956435
    3. Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Bannasch D, et al. Oncogene, 1999 Nov 18. PMID 10597290
    4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified NMI induction as a novel negative feedback mechanism that decreases IRE1alpha-dependent activation of JNK and apoptosis in cytokine-exposed beta cells
      Title: A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112791

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-myc-interactor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034148.2 → NP_001029320.1  N-myc-interactor isoform b

      See identical proteins and their annotated locations for NP_001029320.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q498S7
      Related
      ENSRNOP00000035928.6, ENSRNOT00000030373.6
      Conserved Domains (2) summary
      pfam07292
      Location:170 → 258
      NID; Nmi/IFP 35 domain (NID)
      pfam07334
      Location:1 → 71
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

    2. NM_001431615.1 → NP_001418544.1  N-myc-interactor isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A371, A6JF14

    3. NM_001431616.1 → NP_001418545.1  N-myc-interactor isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A371, A6JF14

    4. NM_001431617.1 → NP_001418546.1  N-myc-interactor isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A371, A6JF14

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      56824778..56848891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104811.2 → XP_038960739.1  N-myc-interactor isoform X1

      Related
      ENSRNOP00000103512.1, ENSRNOT00000172298.1
      Conserved Domains (2) summary
      pfam07334
      Location:27 → 102
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:201 → 289
      NID; Nmi/IFP 35 domain (NID)

    2. XM_039104813.2 → XP_038960741.1  N-myc-interactor isoform X1

      Conserved Domains (2) summary
      pfam07334
      Location:27 → 102
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:201 → 289
      NID; Nmi/IFP 35 domain (NID)

    3. XM_039104814.2 → XP_038960742.1  N-myc-interactor isoform X1

      Conserved Domains (2) summary
      pfam07334
      Location:27 → 102
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:201 → 289
      NID; Nmi/IFP 35 domain (NID)

    4. XM_039104812.2 → XP_038960740.1  N-myc-interactor isoform X1

      UniProtKB/TrEMBL
      A0A8I6A371, A6JF14
      Related
      ENSRNOP00000086226.1, ENSRNOT00000098879.2
      Conserved Domains (2) summary
      pfam07334
      Location:27 → 102
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
      pfam07292
      Location:201 → 289
      NID; Nmi/IFP 35 domain (NID)
    Nucleotide Protein Strain
    Heading Accession and Version

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