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    Slc17a3 solute carrier family 17 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266730, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc17a3provided by RGD
    Official Full Name
    solute carrier family 17 member 3provided by RGD
    Primary source
    RGD:628815
    See related
    EnsemblRapid:ENSRNOG00000032745 AllianceGenome:RGD:628815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnpt4
    Summary
    Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in urate metabolic process; urate transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in endoplasmic reticulum membrane; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 354.3) and Liver (RPKM 290.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc17a3 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41698679..41729057, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41270804..41300132, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43518760..43545160, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 17, member 4 Neighboring gene solute carrier family 17 member 1 Neighboring gene uncharacterized LOC134482855 Neighboring gene solute carrier family 17, member 2 Neighboring gene H1.1 linker histone, cluster member Neighboring gene tripartite motif containing 38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular effects of volume expansion on the renal sodium phosphate cotransporter. Puschett JB, et al. Am J Med Sci, 2003 Jul. PMID 12861119
    2. Identification of a new member of type I Na/phosphate co-transporter in the rat kidney. Ishibashi K, et al. Nephron Physiol, 2003. PMID 12806205
    3. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. Jutabha P, et al. J Biol Chem, 2010 Nov 5. PMID 20810651, Free PMC Article
    4. NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic. Melis D, et al. J Inherit Metab Dis, 2004. PMID 15505377
    5. Sex and age interaction with genetic association of atherogenic uric acid concentrations. Brandstätter A, et al. Atherosclerosis, 2010 Jun. PMID 20053405, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. effects of volume expansion on the renal sodium phosphate cotransporter
      Title: Molecular effects of volume expansion on the renal sodium phosphate cotransporter.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium:phosphate symporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables toxin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transport protein 4
    Names
    Na/Pi cotransporter 4
    sodium-phosphate cotransporter
    solute carrier family 17 (organic anion transporter), member 3
    solute carrier family 17 (sodium phosphate), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153622.2 → NP_705886.1  sodium-dependent phosphate transport protein 4

      See identical proteins and their annotated locations for NP_705886.1

      Status: PROVISIONAL

      Source sequence(s)
      AB025223
      UniProtKB/TrEMBL
      A6KLL0, Q8CJH9
      Related
      ENSRNOP00000029152.4, ENSRNOT00000029626.7
      Conserved Domains (2) summary
      cd06174
      Location:105 → 482
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:27 → 497
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      41698679..41729057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253947.5 → XP_006254009.1  sodium-dependent phosphate transport protein 4 isoform X3

      UniProtKB/TrEMBL
      A6KLL0, Q6AZ69
      Conserved Domains (1) summary
      cd06174
      Location:145 → 493
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. XM_063276121.1 → XP_063132191.1  sodium-dependent phosphate transport protein 4 isoform X8

    3. XM_063276119.1 → XP_063132189.1  sodium-dependent phosphate transport protein 4 isoform X5

      UniProtKB/TrEMBL
      A6KLL0

    4. XM_006253941.5 → XP_006254003.1  sodium-dependent phosphate transport protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006254003.1

      UniProtKB/TrEMBL
      A6KLL0, Q6AZ69
      Conserved Domains (2) summary
      cd06174
      Location:145 → 522
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:71 → 537
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    5. XM_063276118.1 → XP_063132188.1  sodium-dependent phosphate transport protein 4 isoform X4

      UniProtKB/TrEMBL
      A6KLL0, Q6AZ69

    6. XM_006253942.5 → XP_006254004.1  sodium-dependent phosphate transport protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006254004.1

      UniProtKB/TrEMBL
      A6KLL0, Q6AZ69
      Conserved Domains (2) summary
      cd06174
      Location:145 → 522
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:71 → 537
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    7. XM_063276120.1 → XP_063132190.1  sodium-dependent phosphate transport protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JY28, A6KLL0
      Related
      ENSRNOP00000070495.2, ENSRNOT00000091749.3

    8. XM_063276117.1 → XP_063132187.1  sodium-dependent phosphate transport protein 4 isoform X2

      UniProtKB/TrEMBL
      A6KLL0, A6KLL2, E9PTR8

    9. XM_063276116.1 → XP_063132186.1  sodium-dependent phosphate transport protein 4 isoform X1

      UniProtKB/TrEMBL
      A6KLL0, Q6AZ69

    10. XM_039095421.2 → XP_038951349.1  sodium-dependent phosphate transport protein 4 isoform X7

      Conserved Domains (1) summary
      TIGR00894
      Location:71 → 394
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein Strain
    Heading Accession and Version

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