Psma7 proteasome 20S subunit alpha 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psma7provided by RGD
Official Full Name: proteasome 20S subunit alpha 7provided by RGD
Primary source: RGD:61851
See related: EnsemblRapid:ENSRNOG00000056853 AllianceGenome:RGD:61851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 904.1), Thymus (RPKM 898.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (187514901..187521289, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167137279..167143626, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (175420042..175426384, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit alpha type-7

Names: alpha-4; proteasome (prosome, macropain) subunit, alpha type 7; proteasome subunit RC6-1; proteasome subunit alpha 7; proteasome subunit alpha-4

NP_001008218.1

EC 3.4.25.1

XP_063139602.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008217.1 → NP_001008218.1 proteasome subunit alpha type-7

See identical proteins and their annotated locations for NP_001008218.1

Status: VALIDATED

Source sequence(s)

CF110813, CF976316

UniProtKB/TrEMBL

A0A0G2K0W9, A6KMC7

Related

ENSRNOP00000071611.2, ENSRNOT00000082686.3

Conserved Domains (2) summary

PRK03996
Location:1 → 230

PRK03996; proteasome subunit alpha; Provisional

cd03755
Location:3 → 211

proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...