Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sult2a1provided by MGI
Official Full Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1provided by MGI
Primary source: MGI:MGI:98430
See related: Ensembl:ENSMUSG00000078798 AllianceGenome:MGI:98430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Std; Sth1; ST2A1; mSTa1
Summary: Enables alcohol sulfotransferase activity and steroid sulfotransferase activity. Involved in steroid metabolic process. Acts upstream of or within sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; facial prominence; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 20.9) See more
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Genomic context

Location:: 7 A1; 7 8.02 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (13530171..13571335, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (13796246..13837410, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hyposulfatemia leads to hepatic phosphoadenosine-5'-phosphosulfate depletion, which causes loss of SULT2A1 activity and results in accumulation of nonsulfated bile acids and activated farnesoid X receptor activation.
Title: Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency.
and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver
Title: Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
during embryonic development, SULT2B1a produces pregnenolone sulfate, an essential neurosteroid during development of the central nervous system.
Title: Conservation of the hydroxysteroid sulfotransferase SULT2B1 gene structure in the mouse: pre- and postnatal expression, kinetic analysis of isoforms, and comparison with prototypical SULT2A1.
decreased levels or activities of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor during the acute-phase response could contribute to decreases in Sult2A1, resulting in decreased sulfation of DHEA
Title: Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.
Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites in the livers of 4-month- and 20-month-old mice.
Title: Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin.
hydroxysteroid sulfotransferase has a protective role in lithocholic acid-induced liver toxicity
Title: Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
activation of PXR increases the activity and gene expression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD)
Title: Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).
Increased Sult2A1 expression appears to be an adaptive response to ensure optimal metabolism of Sult2A1 substrates at old age.
Title: Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495478

NoName (e-PCR)
- UniSTS:487672

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISO Inferred from Sequence Orthology more info
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables alcohol sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables bile-salt sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables bile-salt sulfotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables steroid sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in sulfation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfotransferase 2A1

Names: ST; bile salt sulfotransferase 1; hydroxysteroid sulfotransferase; sulfotransferase, DHEA preferring; sulfotransferase, hydroxysteroid preferring 1

NP_001104766.1

EC 2.8.2.14

EC 2.8.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.