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    Tincr TINCR ubiquitin domain containing [ Mus musculus (house mouse) ]

    Gene ID: 100504425, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tincrprovided by MGI
    Official Full Name
    TINCR ubiquitin domain containingprovided by MGI
    Primary source
    MGI:MGI:5012404
    See related
    Ensembl:ENSMUSG00000110218 AllianceGenome:MGI:5012404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm20219
    Summary
    This gene encodes a spliced long non-coding RNA. A similar gene in human is associated with epidermal tissue differentiation. [provided by RefSeq, Dec 2014]
    Expression
    Broad expression in stomach adult (RPKM 13.4), bladder adult (RPKM 9.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tincr in Genome Data Viewer
    Location:
    17 D; 17 29.39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56858414..56861403, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56551414..56554387, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10963 Neighboring gene predicted gene, 33258 Neighboring gene zinc and ring finger 4 Neighboring gene scaffold attachment factor B2 Neighboring gene STARR-positive B cell enhancer ABC_E5623 Neighboring gene scaffold attachment factor B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma. Morgado-Palacin L, et al. Nat Commun, 2023 Mar 10. PMID 36899004, Free PMC Article
    2. A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing. Nita A, et al. PLoS Genet, 2021 Aug. PMID 34351912, Free PMC Article
    3. LncRNA Tincr regulates PKCɛ expression in a miR-31-5p-dependent manner in cardiomyocyte hypertrophy. Li H, et al. Naunyn Schmiedebergs Arch Pharmacol, 2020 Dec. PMID 32157348
    4. TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes. Eckhart L, et al. Exp Dermatol, 2020 Apr. PMID 32012357, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A ubiquitin-like protein encoded by the ""noncoding"" RNA TINCR promotes keratinocyte proliferation and wound healing.
      Title: A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing.
    2. LncRNA Tincr regulates PKCvarepsilon expression in a miR-31-5p-dependent manner in cardiomyocyte hypertrophy.
      Title: LncRNA Tincr regulates PKCɛ expression in a miR-31-5p-dependent manner in cardiomyocyte hypertrophy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    TINCR ubiquitin domain containing
    Names
    tissue differentiation-inducing non-protein coding RNA-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396442.1 → NP_001383371.1  TINCR ubiquitin domain containing

      Status: VALIDATED

      Source sequence(s)
      CT485788
      UniProtKB/TrEMBL
      A0A1B0GRQ3
      Related
      ENSMUSP00000159834.1, ENSMUST00000249631.1
      Conserved Domains (1) summary
      cd17039
      Location:18 → 85
      Ubl_ubiquitin_like; ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins

    2. NM_001396443.1 → NP_001383372.1  TINCR ubiquitin domain containing

      Status: VALIDATED

      Source sequence(s)
      CT485788
      UniProtKB/TrEMBL
      A0A1B0GRQ3
      Conserved Domains (1) summary
      cd17039
      Location:18 → 85
      Ubl_ubiquitin_like; ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins

    3. NM_001396444.1 → NP_001383373.1  TINCR ubiquitin domain containing

      Status: VALIDATED

      Source sequence(s)
      CT485788
      UniProtKB/TrEMBL
      A0A1B0GRQ3
      Related
      ENSMUSP00000147618.2, ENSMUST00000209718.3
      Conserved Domains (1) summary
      cd17039
      Location:18 → 85
      Ubl_ubiquitin_like; ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56858414..56861403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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