Spata22 spermatogenesis associated 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata22provided by MGI
Official Full Name: spermatogenesis associated 22provided by MGI
Primary source: MGI:MGI:2685728
See related: Ensembl:ENSMUSG00000112920 AllianceGenome:MGI:2685728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm882
Summary: Acts upstream of or within several processes, including fertilization; meiosis I cell cycle process; and regulation of meiotic cell cycle. Located in chromosome. Is expressed in ileum; male reproductive gland or organ; and ovary. Orthologous to human SPATA22 (spermatogenesis associated 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 2.2), testis adult (RPKM 1.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.29 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (73217416..73237447)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73326560..73346592)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.
Title: shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.
We find that MEIOB and SPATA22 form an obligate complex and contain defined interaction domains
Title: Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks.
Together, these data suggest that SPATA22 is required for both meiotic recombination and synapsis during meiosis in mice.
Title: Spermatogenesis associated 22 is required for DNA repair and synapsis of homologous chromosomes in mouse germ cells.
Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.
Title: Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic DNA repair synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatocyte division	IEA Inferred from Electronic Annotation more info
involved_in spermatocyte division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spermatogenesis-associated protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.