Mas1 MAS1 oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mas1provided by MGI
Official Full Name: MAS1 oncogeneprovided by MGI
Primary source: MGI:MGI:96918
See related: Ensembl:ENSMUSG00000068037 AllianceGenome:MGI:96918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MasR; Mgra; Mas-1
Summary: Enables angiotensin receptor activity and peptide binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction and regulation of inflammatory response. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; extraembryonic component; gut; reproductive system; and spleen. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in testis adult (RPKM 8.4), cortex adult (RPKM 2.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 8.69 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (13056981..13087037, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12838841..12868150, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Title: ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Title: Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging-Related Muscle Weakness in Male Mice.
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Title: Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
Title: Genetic deletion of the angiotensin-(1-7) receptor Mas leads to alterations in gut villi length modulating TLR4/PI3K/AKT and produces microbiome dysbiosis.
Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
Title: Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle.
Title: Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle.
Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
Title: Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
study demonstrates that the activation of MAS is important for microglia recruitment and vascular growth in the developing retina.
Title: The role of receptor MAS in microglia-driven retinal vascular development.
MasR deficiency did not influence body weight, systolic blood pressure at baseline and during AngII infusion, or serum cholesterol concentrations in either Apoe-/- or Ldlr-/- mice. MasR deficiency increased AngII-induced atherosclerosis in aortic arches of Ldlr-/- mice associated with increased oxidative stress and apoptosis in aortic root sections.
Title: Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor.
Title: Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB276039 (e-PCR)
- UniSTS:209271

NoName (e-PCR)
- UniSTS:492207

D17Jcs61 (e-PCR), detects polymorphism
- UniSTS:259296

AW049873 (e-PCR)
- UniSTS:180961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables angiotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables angiotensin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to gonadotropin	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene Mas

Names: MAS proto-oncogene; Mas receptor; Mas-related G protein-coupled receptor a; angiotensin-(1-7) receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008552.5 → NP_032578.2 proto-oncogene Mas

Status: VALIDATED

Source sequence(s)

AK030265, AL589878

Consensus CDS

CCDS28394.1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Related

ENSMUSP00000086409.4, ENSMUST00000089015.10

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

13056981..13087037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523296.5 → XP_006523359.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011246193.3 → XP_011244495.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006523294.4 → XP_006523357.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011246192.3 → XP_011244494.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011246191.3 → XP_011244493.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011246190.3 → XP_011244492.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Related

ENSMUSP00000125108.2, ENSMUST00000162333.8

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_030249523.2 → XP_030105383.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Related

ENSMUSP00000132300.2, ENSMUST00000165020.8

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_030249524.2 → XP_030105384.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006523293.5 → XP_006523356.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017317270.2 → XP_017172759.1 proto-oncogene Mas isoform X1

UniProtKB/Swiss-Prot

O35944, P30554, Q8BHI8

UniProtKB/TrEMBL

Q0VB49, Q9D5Q2

Conserved Domains (1) summary

cd15110
Location:32 → 306

7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors