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    Snrpa small nuclear ribonucleoprotein polypeptide A [ Mus musculus (house mouse) ]

    Gene ID: 53607, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snrpaprovided by MGI
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Aprovided by MGI
    Primary source
    MGI:MGI:1855690
    See related
    Ensembl:ENSMUSG00000061479 AllianceGenome:MGI:1855690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U1A; U1-A; Rnu1a1; Rnu1a-1; C430021M15Rik
    Summary
    Predicted to enable U1 snRNP binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U1 snRNP; U4/U6 x U5 tri-snRNP complex; and spliceosomal complex. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 95.1), limb E14.5 (RPKM 88.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snrpa in Genome Data Viewer
    Location:
    7 A3; 7 15.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26886431..26895696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27187006..27196271, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAB4B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancers ABC_E1725 and ABC_E288 Neighboring gene microRNA 3101 Neighboring gene MIA SH3 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene actin maturation protease Neighboring gene microRNA 1191 Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence analysis of the A protein of the U1 small nuclear ribonucleoprotein particle: the murine protein contains a 5' amino-terminal tag. Bennett MM, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415008, Free PMC Article
    2. Non-snRNP U1A levels decrease during mammalian B-cell differentiation and release the IgM secretory poly(A) site from repression. Ma J, et al. RNA, 2006 Jan. PMID 16373497, Free PMC Article
    3. Tissue-restricted expression of the Cdrap/Mia gene within a conserved multigenic housekeeping locus. Davies SR, et al. Genomics, 2004 Apr. PMID 15028289
    4. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Subramania S, et al. Nucleic Acids Res, 2019 May 7. PMID 30767021, Free PMC Article
    5. Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene. Lee NC, et al. Hum Mol Genet, 2016 Dec 1. PMID 27658936

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
      Title: SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
    2. We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro
      Title: Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene.
    3. a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.
      Title: U1A regulates 3' processing of the survival motor neuron mRNA.
    4. Endogenous non-snRNP associated U1A inhibits poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly (A) site.
      Title: Non-snRNP U1A levels decrease during mammalian B-cell differentiation and release the IgM secretory poly(A) site from repression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables U1 snRNP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein A
    Names
    U1 snRNP A
    protein A of the U1 small nuclear RNA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046637.1 → NP_001040102.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_001040102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC157561, AI851424, AW541778, CX565356
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q52LA2, Q62189
      UniProtKB/TrEMBL
      Q9CXX7
      Related
      ENSMUSP00000131897.3, ENSMUST00000163311.9
      Conserved Domains (3) summary
      COG0724
      Location:7 → 122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13 → 101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208 → 287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    2. NM_001285825.1 → NP_001272754.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_001272754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI851424, CA552113, CX206945, DV650448
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q52LA2, Q62189
      UniProtKB/TrEMBL
      Q9CXX7
      Related
      ENSMUSP00000113678.2, ENSMUST00000122202.8
      Conserved Domains (3) summary
      COG0724
      Location:7 → 122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13 → 101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208 → 287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    3. NM_015782.3 → NP_056597.3  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_056597.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI851424, BC096648, CX206945
      Consensus CDS
      CCDS21014.1
      UniProtKB/Swiss-Prot
      Q52LA2, Q62189
      UniProtKB/TrEMBL
      Q9CXX7
      Related
      ENSMUSP00000079228.4, ENSMUST00000080356.10
      Conserved Domains (3) summary
      COG0724
      Location:7 → 122
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12477
      Location:13 → 101
      RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:208 → 287
      RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26886431..26895696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62189.3 GenPept UniProtKB/Swiss-Prot:Q62189

    Gene LinkOut

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