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    Slfn14 schlafen 14 [ Mus musculus (house mouse) ]

    Gene ID: 237890, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slfn14provided by MGI
    Official Full Name
    schlafen 14provided by MGI
    Primary source
    MGI:MGI:2684866
    See related
    Ensembl:ENSMUSG00000082101 AllianceGenome:MGI:2684866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm20; Slfn14-ps
    Summary
    Enables RNA endonuclease activity and ribosome binding activity. Involved in mRNA catabolic process and rRNA catabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 20. Orthologous to human SLFN14 (schlafen family member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 11.9), liver E14.5 (RPKM 10.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slfn14 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83165936..83177552, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83275110..83286726, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E908 Neighboring gene predicted gene, 23444 Neighboring gene STARR-positive B cell enhancer ABC_E1424 Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene adaptor-related protein complex 2, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to manganese ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein SLFN14
    Names
    Schlafen family member 14, CAST_EiJ strain specific
    Schlafen family member 14, WSB_EiJ strain specific
    schlafen family member 14, pseudogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166028.2NP_001159500.1  protein SLFN14

      Status: VALIDATED

      Source sequence(s)
      AL603711
      Consensus CDS
      CCDS70269.1
      UniProtKB/Swiss-Prot
      V9GXG1
      UniProtKB/TrEMBL
      A0A1G5SK34, A0A1G5SK54
      Related
      ENSMUSP00000139132.2, ENSMUST00000163961.3
      Conserved Domains (2) summary
      PHA02782
      Location:9334
      PHA02782; hypothetical protein; Provisional
      pfam04326
      Location:195305
      AlbA_2; Putative DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83165936..83177552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533236.1XP_006533299.1  protein SLFN14 isoform X1