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    Pls1 plastin 1 (I-isoform) [ Mus musculus (house mouse) ]

    Gene ID: 102502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pls1provided by MGI
    Official Full Name
    plastin 1 (I-isoform)provided by MGI
    Primary source
    MGI:MGI:104809
    See related
    Ensembl:ENSMUSG00000049493 AllianceGenome:MGI:104809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 58.4), small intestine adult (RPKM 19.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pls1 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.22 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95634695..95727359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95752642..95845306, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 2 Neighboring gene predicted gene, 39407 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene VISTA enhancer mm1367 Neighboring gene RIKEN cDNA 1700065D16 gene Neighboring gene STARR-positive B cell enhancer ABC_E5095 Neighboring gene STARR-positive B cell enhancer ABC_E894 Neighboring gene STARR-positive B cell enhancer mm9_chr9:95758941-95759242 Neighboring gene ataxia telangiectasia and Rad3 related Neighboring gene STARR-seq mESC enhancer starr_24939 Neighboring gene predicted gene, 24004

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. L-Plastin promotes podosome longevity and supports macrophage motility. Zhou JY, et al. Mol Immunol, 2016 Oct. PMID 27614263, Free PMC Article
    2. Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice. Taylor R, et al. Hum Mol Genet, 2015 Jan 1. PMID 25124451, Free PMC Article
    3. Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. Krey JF, et al. J Cell Biol, 2016 Nov 21. PMID 27811163, Free PMC Article
    4. L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Deady LE, et al. Infect Immun, 2014 May. PMID 24595139, Free PMC Article
    5. Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Ezzell RM, et al. Development, 1989 Jun. PMID 2686960

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we have identified a role for L-plastin in stabilizing long-lived podosomes and in enabling macrophage motility
      Title: L-Plastin promotes podosome longevity and supports macrophage motility.
    2. PLS1 biases actin toward liquid packing, which allows stereocilia to grow to a greater diameter.
      Title: Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.
    3. Results show that plastin 1 is dispensable for the initial formation of stereocilia.
      Title: Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.
    4. This study identified LPL as being key to alveolar macrophage development and essential to an effective antipneumococcal response.
      Title: L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection.
    5. Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network.
      Title: Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in auditory receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal D-glucose absorption IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in microvillus assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microvillus length IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in terminal web assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within terminal web assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vestibular receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal web IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plastin-1
    Names
    I-fimbrin
    plastin 1, I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033210.4 → NP_001028382.1  plastin-1

      See identical proteins and their annotated locations for NP_001028382.1

      Status: VALIDATED

      Source sequence(s)
      AC091531
      Consensus CDS
      CCDS23412.1
      UniProtKB/Swiss-Prot
      Q3V0K9
      Related
      ENSMUSP00000091317.3, ENSMUST00000093800.9
      Conserved Domains (1) summary
      COG5069
      Location:13 → 622
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

    2. NM_001433803.1 → NP_001420732.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      AC091531
      UniProtKB/Swiss-Prot
      Q3V0K9

    3. NM_001433804.1 → NP_001420733.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      AC091531
      UniProtKB/Swiss-Prot
      Q3V0K9

    4. NM_001433805.1 → NP_001420734.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      AC091531
      UniProtKB/Swiss-Prot
      Q3V0K9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      95634695..95727359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510748.1 → XP_006510811.1  plastin-1 isoform X2

      Conserved Domains (1) summary
      COG5069
      Location:27 → 543
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

    2. XM_006510746.4 → XP_006510809.1  plastin-1 isoform X1

      Conserved Domains (1) summary
      COG5069
      Location:13 → 622
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0K9.1 GenPept UniProtKB/Swiss-Prot:Q3V0K9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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