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    Yme1l1 YME1-like 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 27377, updated on 4-Jan-2025

    Summary

    Official Symbol
    Yme1l1provided by MGI
    Official Full Name
    YME1-like 1 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1351651
    See related
    Ensembl:ENSMUSG00000026775 AllianceGenome:MGI:1351651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftsh; FtsH1
    Summary
    Enables ATP-dependent peptidase activity. Involved in several processes, including mitochondrial protein processing; neuronal stem cell population maintenance; and positive regulation of mitochondrial fusion. Located in mitochondrion. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 18.6), CNS E11.5 (RPKM 15.0) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Yme1l1 in Genome Data Viewer
    Location:
    2 A3; 2 15.24 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23046517..23089272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (23155442..23199260)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2030 Neighboring gene STARR-positive B cell enhancer ABC_E3360 Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene microtubule associated serine/threonine kinase-like Neighboring gene STARR-positive B cell enhancer ABC_E2602 Neighboring gene STARR-positive B cell enhancer ABC_E3361 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene ankyrin repeat domain 68 Neighboring gene predicted gene 13422

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent peptidase activity  
    enables ATP-dependent peptidase activity PubMed 
    enables ATP-dependent peptidase activity PubMed 
    enables ATP-dependent peptidase activity  
    enables ATP-dependent peptidase activity  
    enables DNA clamp loader activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables metal ion binding  
    enables metalloendopeptidase activity  
    Process Evidence Code Pubs
    involved_in cell population proliferation  
    involved_in cell population proliferation  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in mitochondrial protein catabolic process  
    involved_in mitochondrial protein catabolic process  
    involved_in mitochondrial protein processing PubMed 
    involved_in mitochondrial protein processing  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in neuronal stem cell population maintenance PubMed 
    involved_in positive regulation of mitochondrial fusion PubMed 
    involved_in positive regulation of mitochondrial fusion  
    involved_in protein hexamerization  
    involved_in protein hexamerization  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in regulation of stem cell division PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nuclear body  
    located_in nuclear body  

    General protein information

    Preferred Names
    ATP-dependent zinc metalloprotease YME1L1
    Names
    ATP-dependent metalloprotease FtsH1
    YME1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013771.5NP_038799.1  ATP-dependent zinc metalloprotease YME1L1

      See identical proteins and their annotated locations for NP_038799.1

      Status: VALIDATED

      Source sequence(s)
      AF090430, AL928706, BB624412
      Consensus CDS
      CCDS15728.1
      UniProtKB/Swiss-Prot
      O88967, Q7TNN5
      Related
      ENSMUSP00000028117.4, ENSMUST00000028117.4
      Conserved Domains (4) summary
      TIGR01241
      Location:275708
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:317448
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:528706
      Peptidase_M41; Peptidase family M41
      cl21455
      Location:273337
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      23046517..23089272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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