Cdh10 cadherin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh10provided by MGI
Official Full Name: cadherin 10provided by MGI
Primary source: MGI:MGI:107436
See related: Ensembl:ENSMUSG00000022321 AllianceGenome:MGI:107436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A830016G23Rik; C030003B10Rik; C030011H18Rik
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]
Expression: Biased expression in frontal lobe adult (RPKM 9.2), CNS E18 (RPKM 8.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A2; 15 8.2 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (18818763..19014883)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (18818869..19016206)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdh10 which is controlled by Pou3f1, is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
Title: Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.
This demonstration of a distinctive expression pattern of cadherin-10 suggests that it has a pivotal role in the development and maintenance of brain barriers.
Title: Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cdh10 (e-PCR), detects polymorphism
- UniSTS:265057

Cdh10 (e-PCR), detects polymorphism
- UniSTS:546690

CDH10 (e-PCR)
- UniSTS:505806

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cadherin-10

Names: T2-cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316758.1 → NP_001303687.1 cadherin-10 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC121768, AK138606, BB649070, BC052056

Consensus CDS

CCDS37047.1

UniProtKB/Swiss-Prot

P70408, Q3UUB3, Q80WS7

UniProtKB/TrEMBL

Q8VI68

Related

ENSMUSP00000128782.3, ENSMUST00000166873.9

Conserved Domains (3) summary

cd11304
Location:164 → 265

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:80 → 158

CA; Cadherin repeats

pfam01049
Location:643 → 780

Cadherin_C; Cadherin cytoplasmic region
NM_009865.3 → NP_033995.1 cadherin-10 preproprotein

See identical proteins and their annotated locations for NP_033995.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK138606, BC052056

Consensus CDS

CCDS37047.1

UniProtKB/Swiss-Prot

P70408, Q3UUB3, Q80WS7

UniProtKB/TrEMBL

Q8VI68

Related

ENSMUSP00000042199.8, ENSMUST00000040562.14

Conserved Domains (3) summary

cd11304
Location:164 → 265

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:80 → 158

CA; Cadherin repeats

pfam01049
Location:643 → 780

Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

18818763..19014883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520100.5 → XP_006520163.1 cadherin-10 isoform X1

UniProtKB/TrEMBL

Q8VI68

Conserved Domains (3) summary

cd11304
Location:164 → 265

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:80 → 158

CA; Cadherin repeats

pfam01049
Location:633 → 780

Cadherin_C; Cadherin cytoplasmic region