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    Rimklb ribosomal modification protein rimK-like family member B [ Mus musculus (house mouse) ]

    Gene ID: 108653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rimklbprovided by MGI
    Official Full Name
    ribosomal modification protein rimK-like family member Bprovided by MGI
    Primary source
    MGI:MGI:1918325
    See related
    Ensembl:ENSMUSG00000040649 AllianceGenome:MGI:1918325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naags; 4931417E21Rik; 4933426K21Rik
    Summary
    Enables N-acetyl-L-aspartate-L-glutamate ligase activity and citrate-L-glutamate ligase activity. Predicted to be involved in protein modification process. Located in cytoplasm. Is expressed in several structures, including central nervous system; eye; genitourinary system; hindlimb phalanx; and tooth. Orthologous to human RIMKLB (ribosomal modification protein rimK like family member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 16.4), CNS E14 (RPKM 14.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rimklb in Genome Data Viewer
    Location:
    6 F1; 6 57.55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122424255..122464021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122447296..122487062, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700063H04 gene Neighboring gene VISTA enhancer mm94 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17224 Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17225 Neighboring gene STARR-positive B cell enhancer ABC_E10409 Neighboring gene microfibrillar associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E1070 Neighboring gene STARR-positive B cell enhancer ABC_E9100 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122484210-122484511 Neighboring gene STARR-positive B cell enhancer ABC_E11336 Neighboring gene STARR-positive B cell enhancer ABC_E3677 Neighboring gene STARR-positive B cell enhancer ABC_E3678 Neighboring gene activation-induced cytidine deaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Citrylglutamate synthase deficient male mice are subfertile with impaired histone and transition protein 2 removal in late spermatids. Wang-Eckhardt L, et al. Biochem J, 2022 May 13. PMID 35419597
    2. Rimklb mutation causes male infertility in mice. Maekura K, et al. Sci Rep, 2021 Feb 25. PMID 33633267, Free PMC Article
    3. NAAG synthetase deficiency has only low influence on pathogenesis in a Canavan disease mouse model. Becker I, et al. J Inherit Metab Dis, 2024 Mar. PMID 38011891
    4. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. Collard F, et al. J Biol Chem, 2010 Sep 24. PMID 20657015, Free PMC Article
    5. Molecular characterization of N-acetylaspartylglutamate synthetase. Becker I, et al. J Biol Chem, 2010 Sep 17. PMID 20643647, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rimklb mutation causes male infertility in mice.
      Title: Rimklb mutation causes male infertility in mice.
    2. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
      Title: Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyl-L-aspartate-L-glutamate ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyl-L-aspartate-L-glutamate ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables citrate-L-glutamate ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-citrylglutamate synthase B
    Names
    N-acetyl-aspartyl-glutamate synthetase B
    N-acetyl-aspartylglutamate synthetase B
    N-acetylaspartyl-glutamate synthetase B
    NAAG synthetase B
    beta-citryl-glutamate synthase B
    ribosomal protein S6 modification-like protein B
    NP_081940.1
    XP_030110915.1
    XP_030110916.1
    XP_030110917.1
    XP_030110918.1
    XP_036021620.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027664.1 → NP_081940.1  beta-citrylglutamate synthase B

      See identical proteins and their annotated locations for NP_081940.1

      Status: VALIDATED

      Source sequence(s)
      AK039398, AK173135, BB616179, BC052078
      Consensus CDS
      CCDS39622.1
      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Related
      ENSMUSP00000064467.7, ENSMUST00000068242.9
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      122424255..122464021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255058.2 → XP_030110918.1  beta-citrylglutamate synthase B isoform X1

      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. XM_036165727.1 → XP_036021620.1  beta-citrylglutamate synthase B isoform X1

      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    3. XM_030255055.2 → XP_030110915.1  beta-citrylglutamate synthase B isoform X1

      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    4. XM_030255056.2 → XP_030110916.1  beta-citrylglutamate synthase B isoform X1

      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    5. XM_030255057.2 → XP_030110917.1  beta-citrylglutamate synthase B isoform X1

      UniProtKB/Swiss-Prot
      Q69ZN3, Q80WS1, Q8CA77, Q9D3Z1
      Conserved Domains (1) summary
      cl17255
      Location:8 → 303
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RNA

    1. XR_003956144.2 RNA Sequence

    2. XR_003956143.2 RNA Sequence

    3. XR_003956145.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WS1.1 GenPept UniProtKB/Swiss-Prot:Q80WS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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