Ncbp3 nuclear cap binding subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncbp3provided by MGI
Official Full Name: nuclear cap binding subunit 3provided by MGI
Primary source: MGI:MGI:1914124
See related: Ensembl:ENSMUSG00000020783 AllianceGenome:MGI:1914124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200014J11Rik; C130061O14Rik
Summary: Enables RNA cap binding activity. Predicted to be involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human NCBP3 (nuclear cap binding subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.2), CNS E14 (RPKM 3.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.16 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72937443..72974405)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73047867..73083579)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 7-methylguanosine mRNA capping	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	NAS Non-traceable Author Statement more info	PubMed
involved_in snRNA export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear cap binding complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear cap-binding protein subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025818.3 → NP_080094.3 nuclear cap-binding protein subunit 3

See identical proteins and their annotated locations for NP_080094.3

Status: VALIDATED

Source sequence(s)

AK081659, AK153241, AL670399, CJ093775, CN666791

Consensus CDS

CCDS24994.1

UniProtKB/Swiss-Prot

Q3TNF4, Q3TQ96, Q4G0C3, Q8BMB1, Q8BZR9, Q9CRM6, Q9CS93, Q9D0G9, Q9DBT0

UniProtKB/TrEMBL

Q7TPS9

Related

ENSMUSP00000021135.4, ENSMUST00000021135.5

Conserved Domains (1) summary

pfam10309
Location:123 → 177

DUF2414; Protein of unknown function (DUF2414)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

72937443..72974405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156901.1 → XP_036012794.1 nuclear cap-binding protein subunit 3 isoform X1

Conserved Domains (1) summary

pfam10309
Location:123 → 177

NCBP3; Nuclear cap-binding protein subunit 3