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    Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16519, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnj3provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 3provided by MGI
    Primary source
    MGI:MGI:104742
    See related
    Ensembl:ENSMUSG00000026824 AllianceGenome:MGI:104742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GIRK1; Kcnf3; Kcnj1; GIRK-1; Kir3.1
    Summary
    Predicted to enable inward rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.5), heart adult (RPKM 8.9) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnj3 in Genome Data Viewer
    Location:
    2 C1.1; 2 31.66 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (55301814..55488157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (55411798..55598145)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 13 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene oral-facial-digital syndrome 1 gene homolog pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124233, MGC124234

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of I(KACh) inward rectifier potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G protein-activated inward rectifier potassium channel 1
    Names
    G protein-gated K+ channel subunit 1 GIRK1
    inward rectifier K(+) channel Kir3.1
    potassium channel, inwardly rectifying subfamily J member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304810.1NP_001291739.1  G protein-activated inward rectifier potassium channel 1 isoform 2

      See identical proteins and their annotated locations for NP_001291739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL929253, AW488293, BC068167
      Consensus CDS
      CCDS84524.1
      UniProtKB/TrEMBL
      B1AYE4, Q8VHS4
      Related
      ENSMUSP00000108251.2, ENSMUST00000112632.2
      Conserved Domains (1) summary
      cl21560
      Location:47234
      Ion_trans_2; Ion channel
    2. NM_001355118.1NP_001342047.1  G protein-activated inward rectifier potassium channel 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL845483, AL929253
      Consensus CDS
      CCDS16042.1
      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    3. NM_008426.2NP_032452.1  G protein-activated inward rectifier potassium channel 1 isoform 1

      See identical proteins and their annotated locations for NP_032452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL929253, AW488293, BC068167
      Consensus CDS
      CCDS16042.1
      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Related
      ENSMUSP00000063329.4, ENSMUST00000067101.10
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      55301814..55488157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247723.2XP_030103583.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    2. XM_036158746.1XP_036014639.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    3. XM_030247737.2XP_030103597.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    4. XM_030247725.2XP_030103585.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    5. XM_030247736.2XP_030103596.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    6. XM_030247738.2XP_030103598.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    7. XM_030247730.2XP_030103590.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    8. XM_030247739.2XP_030103599.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    9. XM_030247729.2XP_030103589.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    10. XM_030247740.2XP_030103600.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    11. XM_036158749.1XP_036014642.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    12. XM_030247752.2XP_030103612.1  G protein-activated inward rectifier potassium channel 1 isoform X3

      Conserved Domains (1) summary
      pfam17655
      Location:2132
      IRK_C; Inward rectifier potassium channel C-terminal domain
    13. XM_030247722.2XP_030103582.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    14. XM_030247751.2XP_030103611.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    15. XM_030247749.2XP_030103609.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194364
      IRK_C; Inward rectifier potassium channel C-terminal domain
    16. XM_006497731.5XP_006497794.1  G protein-activated inward rectifier potassium channel 1 isoform X2

      UniProtKB/TrEMBL
      Q8VHS4
      Conserved Domains (2) summary
      pfam01007
      Location:47187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194240
      IRK_C; Inward rectifier potassium channel C-terminal domain