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    Rsph14 radial spoke head homolog 14 (Chlamydomonas) [ Mus musculus (house mouse) ]

    Gene ID: 71236, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rsph14provided by MGI
    Official Full Name
    radial spoke head homolog 14 (Chlamydomonas)provided by MGI
    Primary source
    MGI:MGI:1918486
    See related
    Ensembl:ENSMUSG00000009070 AllianceGenome:MGI:1918486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rtdr1; 4933431K05Rik
    Summary
    Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and mating. Part of radial spoke. Is expressed in lung epithelium and nasal cavity respiratory epithelium. Orthologous to human RSPH14 (radial spoke head 14 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 5.7), ovary adult (RPKM 0.8) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Rsph14 in Genome Data Viewer
    Location:
    10 B5.3; 10 38.48 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (74793309..74868475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (74957477..75032642, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene 6419 Neighboring gene STARR-seq mESC enhancer starr_27145 Neighboring gene guanine nucleotide binding protein, alpha z subunit Neighboring gene predicted gene, 40692 Neighboring gene RAB36, member RAS oncogene family Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene STARR-positive B cell enhancer ABC_E10622 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74614065-74614365

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Zhang X, et al. Cell Rep, 2022 Nov 22. PMID 36417862
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in epithelial cilium movement involved in extracellular fluid movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in flagellated sperm motility IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mating IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of radial spoke IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    radial spoke head 14 homolog
    Names
    rhabdoid tumor deletion region gene 1
    rhabdoid tumor deletion region protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163533.1 → NP_001157005.1  radial spoke head 14 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC142500, AK017008, BB616907
      Consensus CDS
      CCDS48597.1
      UniProtKB/TrEMBL
      E9PWZ8
      Related
      ENSMUSP00000131632.2, ENSMUST00000166088.8
      Conserved Domains (4) summary
      cd00020
      Location:257 → 370
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:184 → 287
      HEAT_2; HEAT repeats
      sd00044
      Location:184 → 208
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:223 → 248
      ARM; armadillo repeat [structural motif]

    2. NM_001163534.1 → NP_001157006.1  radial spoke head 14 homolog isoform 3

      See identical proteins and their annotated locations for NP_001157006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AK017008, BB616907, BC147801
      Consensus CDS
      CCDS48596.1
      UniProtKB/Swiss-Prot
      Q9D3W1
      Related
      ENSMUSP00000136715.2, ENSMUST00000179546.8
      Conserved Domains (4) summary
      cd00020
      Location:224 → 337
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:151 → 254
      HEAT_2; HEAT repeats
      sd00044
      Location:151 → 175
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:190 → 215
      ARM; armadillo repeat [structural motif]

    3. NM_001163535.1 → NP_001157007.1  radial spoke head 14 homolog isoform 3

      See identical proteins and their annotated locations for NP_001157007.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, which result in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AK017008, BC147792, BY716693
      Consensus CDS
      CCDS48596.1
      UniProtKB/Swiss-Prot
      Q9D3W1
      Related
      ENSMUSP00000009214.4, ENSMUST00000009214.10
      Conserved Domains (4) summary
      cd00020
      Location:224 → 337
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:151 → 254
      HEAT_2; HEAT repeats
      sd00044
      Location:151 → 175
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:190 → 215
      ARM; armadillo repeat [structural motif]

    4. NM_027730.1 → NP_082006.1  radial spoke head 14 homolog isoform 2

      See identical proteins and their annotated locations for NP_082006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AK017008, BB616907
      UniProtKB/Swiss-Prot
      Q9D3W1
      Conserved Domains (4) summary
      cd00020
      Location:256 → 369
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:183 → 286
      HEAT_2; HEAT repeats
      sd00044
      Location:183 → 207
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:222 → 247
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      74793309..74868475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514117.5 → XP_006514180.1  radial spoke head 14 homolog isoform X1

      Conserved Domains (3) summary
      sd00044
      Location:102 → 126
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:177 → 208
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:253 → 286
      Arm; Armadillo/beta-catenin-like repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3W1.1 GenPept UniProtKB/Swiss-Prot:Q9D3W1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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