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    Mtx2 metaxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 53375, updated on 13-Jan-2025

    Summary

    Official Symbol
    Mtx2provided by MGI
    Official Full Name
    metaxin 2provided by MGI
    Primary source
    MGI:MGI:1859652
    See related
    Ensembl:ENSMUSG00000027099 AllianceGenome:MGI:1859652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500012G02Rik
    Summary
    Predicted to be involved in mitochondrial transport and mitochondrion organization. Located in mitochondrion. Is expressed in central nervous system; embryo; and retina. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 50.4), duodenum adult (RPKM 32.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtx2 in Genome Data Viewer
    Location:
    2 C3; 2 44.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74656156..74707092)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74825812..74876748)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14424 Neighboring gene Hoxd antisense growth associated long non-coding RNA Neighboring gene homeobox D1 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:74857649-74857758 Neighboring gene STARR-seq mESC enhancer starr_04859 Neighboring gene STARR-seq mESC enhancer starr_04860 Neighboring gene STARR-seq mESC enhancer starr_04861 Neighboring gene predicted gene, 46748

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mitochondrial transport  
    involved_in mitochondrial transport  
    involved_in mitochondrion organization  
    involved_in protein transport  
    Component Evidence Code Pubs
    part_of SAM complex  
    part_of SAM complex  
    part_of SAM complex  
    is_active_in cytoplasm  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  

    General protein information

    Preferred Names
    metaxin-2
    Names
    mitochondrial outer membrane import complex protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016804.4NP_058084.3  metaxin-2

      See identical proteins and their annotated locations for NP_058084.3

      Status: VALIDATED

      Source sequence(s)
      AK083055, AK169048, BY126313
      Consensus CDS
      CCDS16148.1
      UniProtKB/Swiss-Prot
      O88441, Q3TFR2
      UniProtKB/TrEMBL
      Q3TI19, Q3TI40
      Related
      ENSMUSP00000028511.8, ENSMUST00000028511.8
      Conserved Domains (3) summary
      cd03211
      Location:125250
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      COG0625
      Location:33252
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03079
      Location:2295
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      74656156..74707092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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