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    Slc25a40 solute carrier family 25, member 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a40provided by RGD
    Official Full Name
    solute carrier family 25, member 40provided by RGD
    Primary source
    RGD:1308774
    See related
    EnsemblRapid:ENSRNOG00000022837 AllianceGenome:RGD:1308774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308774
    Summary
    Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in erythrocyte development and import into the mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 67.5), Kidney (RPKM 66.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a40 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26544288..26631439, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25631447..25676454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22619700..22661685, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene ATP binding cassette subfamily B member 1A Neighboring gene RUN domain containing 3B Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene transfer RNA proline (anticodon AGG) 72

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112631

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial glutathione transporter SLC25A40; probable mitochondrial glutathione transporter SLC25A40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393710.1 → NP_001380639.1  mitochondrial glutathione transporter SLC25A40

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q498U3
      UniProtKB/TrEMBL
      A0A8I5ZJJ7
      Related
      ENSRNOP00000077662.2, ENSRNOT00000098158.2
      Conserved Domains (1) summary
      pfam00153
      Location:13 → 137
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26544288..26631439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285716.1 → XP_063141786.1  probable mitochondrial glutathione transporter SLC25A40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJJ7
      Related
      ENSRNOP00000058058.3, ENSRNOT00000061342.7

    2. XM_063285717.1 → XP_063141787.1  probable mitochondrial glutathione transporter SLC25A40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJJ7

    3. XM_063285721.1 → XP_063141791.1  probable mitochondrial glutathione transporter SLC25A40 isoform X5

    4. XM_063285720.1 → XP_063141790.1  probable mitochondrial glutathione transporter SLC25A40 isoform X4

    5. XM_063285719.1 → XP_063141789.1  probable mitochondrial glutathione transporter SLC25A40 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZJJ7, A0A8L2QG81
      Related
      ENSRNOP00000029371.6, ENSRNOT00000030352.8

    6. XM_063285718.1 → XP_063141788.1  probable mitochondrial glutathione transporter SLC25A40 isoform X2

      UniProtKB/Swiss-Prot
      Q498U3
      UniProtKB/TrEMBL
      A0A8I5ZJJ7

    RNA

    1. XR_010065616.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037186.1: Suppressed sequence

      Description
      NM_001037186.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498U3.2 GenPept UniProtKB/Swiss-Prot:Q498U3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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