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    Ube4a ubiquitination factor E4A [ Mus musculus (house mouse) ]

    Gene ID: 140630, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ube4aprovided by MGI
    Official Full Name
    ubiquitination factor E4Aprovided by MGI
    Primary source
    MGI:MGI:2154580
    See related
    Ensembl:ENSMUSG00000059890 AllianceGenome:MGI:2154580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UFD2b; 4732444G18Rik; 9930123J21Rik
    Summary
    Enables ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in cytoplasm. Is expressed in ganglia; medulla oblongata basal plate; thymus primordium; ventral grey horn; and vibrissa. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.1), whole brain E14.5 (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube4a in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44834425..44877021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44923127..44965615, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26249 Neighboring gene ATP synthase membrane subunit g Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44728805-44728988 Neighboring gene predicted gene, 30934 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44773592-44773779 Neighboring gene CD3 antigen, gamma polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CD3 antigen, delta polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo. Mukherjee S, et al. Mol Metab, 2023 Sep. PMID 37429524, Free PMC Article
    2. Loss of FoxOs in muscle increases strength and mitochondrial function during aging. Penniman CM, et al. J Cachexia Sarcopenia Muscle, 2023 Feb. PMID 36442857, Free PMC Article
    3. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
    4. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
      Title: Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
    2. Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
      Title: Loss of FoxOs in muscle increases strength and mitochondrial function during aging.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugation factor E4 A
    Names
    ubiquitination factor E4A, UFD2 homolog
    NP_001333627.1
    NP_001348004.1
    NP_001348005.1
    NP_663375.3
    XP_006510065.1
    XP_006510066.1
    XP_011240696.1
    XP_011240697.1
    XP_011240698.1
    XP_030099909.1
    XP_030099910.1
    XP_030099911.1
    XP_030099912.1
    XP_036010503.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346698.1 → NP_001333627.1  ubiquitin conjugation factor E4 A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166048
      Consensus CDS
      CCDS85670.1
      UniProtKB/TrEMBL
      G3X9Y5, Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:1009 → 1078
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:349 → 990
      Ufd2P_core; Ubiquitin elongating factor core

    2. NM_001361075.1 → NP_001348004.1  ubiquitin conjugation factor E4 A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166048, AK028850
      Consensus CDS
      CCDS90555.1
      UniProtKB/TrEMBL
      Q8VDS1
      Related
      ENSMUSP00000149791.2, ENSMUST00000138559.9

    3. NM_001361076.1 → NP_001348005.1  ubiquitin conjugation factor E4 A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166048
      UniProtKB/TrEMBL
      I6L960
      Conserved Domains (1) summary
      pfam10408
      Location:253 → 846
      Ufd2P_core; Ubiquitin elongating factor core

    4. NM_145400.3 → NP_663375.3  ubiquitin conjugation factor E4 A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166048, AK172893, CN705350
      Consensus CDS
      CCDS23122.2
      UniProtKB/Swiss-Prot
      E9Q735
      UniProtKB/TrEMBL
      Q6A0C5
      Related
      ENSMUSP00000113346.2, ENSMUST00000117506.9
      Conserved Domains (2) summary
      pfam10408
      Location:330 → 933
      Ufd2P_core; Ubiquitin elongating factor core
      cd16657
      Location:952 → 1021
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins

    RNA

    1. NR_153962.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166048
      Related
      ENSMUST00000154287.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44834425..44877021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510002.4 → XP_006510065.1  ubiquitin conjugation factor E4 A isoform X1

      UniProtKB/TrEMBL
      G3X9Y5, Q6A0C5
      Related
      ENSMUSP00000112632.2, ENSMUST00000117549.8
      Conserved Domains (2) summary
      cd16657
      Location:1009 → 1078
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:349 → 990
      Ufd2P_core; Ubiquitin elongating factor core

    2. XM_030244049.1 → XP_030099909.1  ubiquitin conjugation factor E4 A isoform X2

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:990 → 1059
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:330 → 971
      Ufd2P_core; Ubiquitin elongating factor core

    3. XM_030244052.1 → XP_030099912.1  ubiquitin conjugation factor E4 A isoform X4

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:913 → 982
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:253 → 894
      Ufd2P_core; Ubiquitin elongating factor core

    4. XM_006510003.5 → XP_006510066.1  ubiquitin conjugation factor E4 A isoform X2

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:990 → 1059
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:330 → 971
      Ufd2P_core; Ubiquitin elongating factor core

    5. XM_011242395.4 → XP_011240697.1  ubiquitin conjugation factor E4 A isoform X1

      UniProtKB/TrEMBL
      G3X9Y5, Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:1009 → 1078
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:349 → 990
      Ufd2P_core; Ubiquitin elongating factor core

    6. XM_011242396.4 → XP_011240698.1  ubiquitin conjugation factor E4 A isoform X2

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:990 → 1059
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:330 → 971
      Ufd2P_core; Ubiquitin elongating factor core

    7. XM_011242394.4 → XP_011240696.1  ubiquitin conjugation factor E4 A isoform X1

      UniProtKB/TrEMBL
      G3X9Y5, Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:1009 → 1078
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:349 → 990
      Ufd2P_core; Ubiquitin elongating factor core

    8. XM_030244050.2 → XP_030099910.1  ubiquitin conjugation factor E4 A isoform X4

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:913 → 982
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:253 → 894
      Ufd2P_core; Ubiquitin elongating factor core

    9. XM_030244051.2 → XP_030099911.1  ubiquitin conjugation factor E4 A isoform X4

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      cd16657
      Location:913 → 982
      RING-Ubox_UBE4A; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 A (UBE4A) and similar proteins
      pfam10408
      Location:253 → 894
      Ufd2P_core; Ubiquitin elongating factor core

    10. XM_036154610.1 → XP_036010503.1  ubiquitin conjugation factor E4 A isoform X3

      UniProtKB/TrEMBL
      Q6A0C5
      Conserved Domains (2) summary
      pfam10408
      Location:349 → 990
      Ufd2P_core; Ubiquitin elongating factor core
      cl17238
      Location:1009 → 1044
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q735.1 GenPept UniProtKB/Swiss-Prot:E9Q735

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