Arl6ip1 ARL6 interacting reticulophagy regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arl6ip1provided by RGD
Official Full Name: ARL6 interacting reticulophagy regulator 1provided by RGD
Primary source: RGD:735205
See related: EnsemblRapid:ENSRNOG00000017751 AllianceGenome:RGD:735205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including endoplasmic reticulum tubular network organization; negative regulation of cysteine-type endopeptidase activity; and positive regulation of L-glutamate import across plasma membrane. Predicted to be located in cytosol and endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Predicted to be active in endoplasmic reticulum tubular network and membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ARL6 interacting reticulophagy regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 820.2), Kidney (RPKM 696.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (181864717..181874232, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (172430475..172439990, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (187770160..187779675, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127140 (e-PCR)
- UniSTS:208189

RH128475 (e-PCR)
- UniSTS:211783

D18377 (e-PCR)
- UniSTS:124775

RH129277 (e-PCR)
- UniSTS:212584

AI236718 (e-PCR)
- UniSTS:250620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network formation	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sec61 translocon complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 6-interacting protein 1

Names: ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation-like factor 6-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198737.2 → NP_942032.1 ADP-ribosylation factor-like protein 6-interacting protein 1

See identical proteins and their annotated locations for NP_942032.1

Status: PROVISIONAL

Source sequence(s)

BC099071

UniProtKB/TrEMBL

F7EPD6, Q7TMZ5

Related

ENSRNOP00000024648.4, ENSRNOT00000024648.10

Conserved Domains (1) summary

cl41772
Location:34 → 200

Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins