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    Plxna2 plexin A2 [ Mus musculus (house mouse) ]

    Gene ID: 18845, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plxna2provided by MGI
    Official Full Name
    plexin A2provided by MGI
    Primary source
    MGI:MGI:107684
    See related
    Ensembl:ENSMUSG00000026640 AllianceGenome:MGI:107684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OCT; Plxn2; PlexA2; mKIAA0463; 2810428A13Rik
    Summary
    Enables identical protein binding activity and semaphorin receptor activity. Involved in several processes, including chordate embryonic development; limb bud formation; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway; centrosome localization; and cerebellar granule cell precursor tangential migration. Located in plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and peripheral nervous system. Orthologous to human PLXNA2 (plexin A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 20.1), whole brain E14.5 (RPKM 19.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Plxna2 in Genome Data Viewer
    Location:
    1 H6; 1 98.27 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194302020..194499177)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (194619791..194816869)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31988 Neighboring gene predicted gene, 51784 Neighboring gene STARR-seq mESC enhancer starr_03492 Neighboring gene STARR-seq mESC enhancer starr_03493 Neighboring gene STARR-seq mESC enhancer starr_03494 Neighboring gene STARR-seq mESC enhancer starr_03495 Neighboring gene STARR-seq mESC enhancer starr_03496 Neighboring gene STARR-seq mESC enhancer starr_03498 Neighboring gene predicted gene, 46202 Neighboring gene prefoldin subunit 1-like Neighboring gene microRNA 3962

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables semaphorin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables semaphorin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    plexin-A2
    Names
    plex 2
    plexin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008882.2NP_032908.2  plexin-A2 precursor

      See identical proteins and their annotated locations for NP_032908.2

      Status: VALIDATED

      Source sequence(s)
      AA289826, AC162447, BC068155, BY753209, D86949
      Consensus CDS
      CCDS35827.1
      UniProtKB/Swiss-Prot
      P70207, Q6NVE6, Q6PHN4, Q80TZ7, Q8R1I4
      Related
      ENSMUSP00000027952.6, ENSMUST00000027952.12
      Conserved Domains (7) summary
      cd11272
      Location:38552
      Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
      cd01179
      Location:9541037
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:858953
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10411141
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:806855
      PSI; Plexin repeat
      pfam01833
      Location:11431227
      TIG; IPT/TIG domain
      pfam08337
      Location:13111864
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      194302020..194499177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497240.5XP_006497303.1  plexin-A2 isoform X1

      Conserved Domains (9) summary
      cd11272
      Location:38552
      Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
      cd01179
      Location:9541037
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:858953
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10411141
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:806855
      PSI; Plexin repeat
      pfam01833
      Location:11431227
      TIG; IPT/TIG domain
      pfam08337
      Location:13111870
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:566654
      TIG_plexin; TIG domain
      pfam18020
      Location:708802
      TIG_2; TIG domain found in plexin
    2. XM_036162782.1XP_036018675.1  plexin-A2 isoform X2

      Conserved Domains (4) summary
      cd11272
      Location:38552
      Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
      pfam01437
      Location:806855
      PSI; Plexin repeat
      pfam17960
      Location:565654
      TIG_plexin; TIG domain
      pfam18020
      Location:708802
      TIG_2; TIG domain found in plexin

    RNA

    1. XR_373891.5 RNA Sequence