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    Ttc4 tetratricopeptide repeat domain 4 [ Mus musculus (house mouse) ]

    Gene ID: 72354, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttc4provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 4provided by MGI
    Primary source
    MGI:MGI:1919604
    See related
    Ensembl:ENSMUSG00000025413 AllianceGenome:MGI:1919604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L62; 2810002P21Rik
    Summary
    Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Predicted to be involved in defense response to virus; innate immune response; and protein folding. Located in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; olfactory epithelium; renal cortex; and thymus primordium. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 33.7), CNS E18 (RPKM 31.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ttc4 in Genome Data Viewer
    Location:
    4 C7; 4 49.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106514952..106536188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106656806..106679002, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10244 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene prolyl-tRNA synthetase (mitochondrial)(putative) Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence simliarity 151, member A Neighboring gene acyl-CoA thioesterase 11 Neighboring gene STARR-positive B cell enhancer ABC_E4640

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 4
    Names
    TPR repeat protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172073.1NP_001165544.1  tetratricopeptide repeat protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001165544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK005923, AK133931
      UniProtKB/TrEMBL
      Q3UZC4
      Related
      ENSMUST00000142342.8
      Conserved Domains (2) summary
      TIGR00990
      Location:28173
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:3462
      TPR; TPR repeat [structural motif]
    2. NM_028209.2NP_082485.1  tetratricopeptide repeat protein 4 isoform 1

      See identical proteins and their annotated locations for NP_082485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AK005923, AK012652, AK133931, BY060470
      Consensus CDS
      CCDS18424.1
      UniProtKB/Swiss-Prot
      Q8R3H9
      UniProtKB/TrEMBL
      Q3UZC4
      Related
      ENSMUSP00000026480.7, ENSMUST00000026480.13
      Conserved Domains (2) summary
      sd00006
      Location:79107
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:78148
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106514952..106536188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503408.5XP_006503471.1  tetratricopeptide repeat protein 4 isoform X1

      UniProtKB/TrEMBL
      Q3UZC4
      Conserved Domains (2) summary
      TIGR00990
      Location:73218
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:79107
      TPR; TPR repeat [structural motif]
    2. XM_036164455.1XP_036020348.1  tetratricopeptide repeat protein 4 isoform X3

      Conserved Domains (1) summary
      pfam18972
      Location:71155
      Wheel; Cns1/TTC4 Wheel domain
    3. XM_006503409.5XP_006503472.1  tetratricopeptide repeat protein 4 isoform X2

      UniProtKB/TrEMBL
      Q3UZC4
      Conserved Domains (2) summary
      TIGR00990
      Location:28173
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:3462
      TPR; TPR repeat [structural motif]