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    Amfr autocrine motility factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 23802, updated on 3-Dec-2024

    Summary

    Official Symbol
    Amfrprovided by MGI
    Official Full Name
    autocrine motility factor receptorprovided by MGI
    Primary source
    MGI:MGI:1345634
    See related
    Ensembl:ENSMUSG00000031751 AllianceGenome:MGI:1345634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gp78
    Summary
    Predicted to enable several functions, including BAT3 complex binding activity; ubiquitin-specific protease binding activity; and ubiquitin-ubiquitin ligase activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and perinuclear region of cytoplasm. Predicted to be part of Derlin-1 retrotranslocation complex and ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 95.7), liver adult (RPKM 63.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Amfr in Genome Data Viewer
    Location:
    8 C5; 8 45.96 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94698216..94739301, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93971588..94012640, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930488L21 gene Neighboring gene guanine nucleotide binding protein, alpha O Neighboring gene STARR-seq mESC enhancer starr_22343 Neighboring gene STARR-seq mESC enhancer starr_22344 Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene nudix hydrolase 21 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BAT3 complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables BAT3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-ubiquitin ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase AMFR
    Names
    AMF receptor
    RING-type E3 ubiquitin transferase AMFR
    NP_001401199.1
    NP_001401200.1
    NP_001401201.1
    NP_001401202.1
    NP_001401203.1
    NP_001401204.1
    NP_001401205.1
    NP_035917.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414270.1NP_001401199.1  E3 ubiquitin-protein ligase AMFR isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    2. NM_001414271.1NP_001401200.1  E3 ubiquitin-protein ligase AMFR isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    3. NM_001414272.1NP_001401201.1  E3 ubiquitin-protein ligase AMFR isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    4. NM_001414273.1NP_001401202.1  E3 ubiquitin-protein ligase AMFR isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    5. NM_001414274.1NP_001401203.1  E3 ubiquitin-protein ligase AMFR isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    6. NM_001414275.1NP_001401204.1  E3 ubiquitin-protein ligase AMFR isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC138118
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3U007
    7. NM_001414276.1NP_001401205.1  E3 ubiquitin-protein ligase AMFR isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC138118
    8. NM_011787.3NP_035917.2  E3 ubiquitin-protein ligase AMFR isoform 1

      See identical proteins and their annotated locations for NP_035917.2

      Status: VALIDATED

      Source sequence(s)
      AC138118
      Consensus CDS
      CCDS22533.1
      UniProtKB/Swiss-Prot
      Q8K008, Q99LH5, Q9R049
      UniProtKB/TrEMBL
      Q3TCI2, Q3U007
      Related
      ENSMUSP00000052258.7, ENSMUST00000053766.14
      Conserved Domains (3) summary
      COG5243
      Location:82378
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14421
      Location:454494
      CUE_AMFR; CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins
      pfam13639
      Location:335375
      zf-RING_2; Ring finger domain

    RNA

    1. NR_182267.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138118

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94698216..94739301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)