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    Pycr2 pyrroline-5-carboxylate reductase family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 69051, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pycr2provided by MGI
    Official Full Name
    pyrroline-5-carboxylate reductase family, member 2provided by MGI
    Primary source
    MGI:MGI:1277956
    See related
    Ensembl:ENSMUSG00000026520 AllianceGenome:MGI:1277956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P5cr2; 1810018M05Rik
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process and cellular response to oxidative stress. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 10. Orthologous to human PYCR2 (pyrroline-5-carboxylate reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 34.4), ovary adult (RPKM 30.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pycr2 in Genome Data Viewer
    Location:
    1 H4; 1 84.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180731839..180735653)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180904274..180908088)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182805483-182805670 Neighboring gene predicted gene, 39714 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182814007-182814116 Neighboring gene STARR-seq mESC enhancer starr_03220 Neighboring gene left-right determination factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2592 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182834193-182834494 Neighboring gene predicted gene, 32199 Neighboring gene STARR-positive B cell enhancer ABC_E10069 Neighboring gene STARR-seq mESC enhancer starr_03222 Neighboring gene predicted gene, 39715 Neighboring gene left right determination factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proline biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    pyrroline-5-carboxylate reductase 2
    Names
    P5C reductase 2
    P5CR 2
    NP_598466.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133705.2NP_598466.1  pyrroline-5-carboxylate reductase 2

      See identical proteins and their annotated locations for NP_598466.1

      Status: VALIDATED

      Source sequence(s)
      AI847678, AK165618, CJ154235
      Consensus CDS
      CCDS15576.1
      UniProtKB/Swiss-Prot
      Q922Q4
      UniProtKB/TrEMBL
      Q3TJ21, Q3TMZ1
      Related
      ENSMUSP00000027802.8, ENSMUST00000027802.9
      Conserved Domains (1) summary
      PLN02688
      Location:1268
      PLN02688; pyrroline-5-carboxylate reductase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180731839..180735653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)