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    Acacb acetyl-Coenzyme A carboxylase beta [ Mus musculus (house mouse) ]

    Gene ID: 100705, updated on 3-Dec-2024

    Summary

    Official Symbol
    Acacbprovided by MGI
    Official Full Name
    acetyl-Coenzyme A carboxylase betaprovided by MGI
    Primary source
    MGI:MGI:2140940
    See related
    Ensembl:ENSMUSG00000042010 AllianceGenome:MGI:2140940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acc2; Accb
    Summary
    Enables acetyl-CoA carboxylase activity. Involved in several processes, including malonyl-CoA biosynthetic process; negative regulation of fatty acid beta-oxidation; and positive regulation of heart growth. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 37.5), heart adult (RPKM 32.1) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Acacb in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    57
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114284748..114388822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114146321..114250761)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14065 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene uracil DNA glycosylase Neighboring gene STARR-seq mESC enhancer starr_14069 Neighboring gene STARR-seq mESC enhancer starr_14070 Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene myosin 1H Neighboring gene potassium channel tetramerisation domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acetyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables biotin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables biotin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular aspartate homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular aspartate homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular glutamate homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glutamate homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in malonyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acetyl-CoA carboxylase 2
    Names
    ACC-beta
    NP_001390456.1
    NP_001390457.1
    NP_001390458.1
    NP_598665.2
    XP_006530175.1
    XP_006530177.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403527.1NP_001390456.1  acetyl-CoA carboxylase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122282
    2. NM_001403528.1NP_001390457.1  acetyl-CoA carboxylase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122282
      UniProtKB/TrEMBL
      Q3UHC8
      Related
      ENSMUST00000143276.2
    3. NM_001403529.1NP_001390458.1  acetyl-CoA carboxylase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122282
    4. NM_133904.3NP_598665.2  acetyl-CoA carboxylase 2 isoform 2

      See identical proteins and their annotated locations for NP_598665.2

      Status: VALIDATED

      Source sequence(s)
      AC122282
      Consensus CDS
      CCDS19561.1
      UniProtKB/Swiss-Prot
      E9Q4Z2, Q6JIZ0
      Related
      ENSMUSP00000099642.2, ENSMUST00000102582.8
      Conserved Domains (4) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:887951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17702324
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:9521678
      ACC_central; Acetyl-CoA carboxylase, central region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114284748..114388822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530112.4XP_006530175.1  acetyl-CoA carboxylase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530175.1

      Conserved Domains (4) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:887951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17912345
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:9521699
      ACC_central; Acetyl-CoA carboxylase, central region
    2. XM_006530114.5XP_006530177.1  acetyl-CoA carboxylase 2 isoform X3

      Conserved Domains (4) summary
      COG0439
      Location:58561
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00364
      Location:695759
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:15992153
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:7601507
      ACC_central; Acetyl-CoA carboxylase, central region