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    Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 79235, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lratprovided by MGI
    Official Full Name
    lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)provided by MGI
    Primary source
    MGI:MGI:1891259
    See related
    Ensembl:ENSMUSG00000028003 AllianceGenome:MGI:1891259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300010A18Rik
    Summary
    Enables phosphatidylcholine-retinol O-acyltransferase activity. Involved in retinol metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and vitamin A metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including extraembryonic component; gut; midbrain; reproductive system; and retina. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 4.4), ovary adult (RPKM 2.9) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrat in Genome Data Viewer
    Location:
    3 E3; 3 36.81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82799889..82811281, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (82892582..82903974, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29999 Neighboring gene STARR-seq mESC enhancer starr_08040 Neighboring gene STARR-seq mESC enhancer starr_08041 Neighboring gene RNA binding motif protein 46 Neighboring gene RNA binding motif protein 46, opposite strand Neighboring gene predicted gene, 30097 Neighboring gene STARR-seq mESC enhancer starr_08043 Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen alpha chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables O-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylcholine-retinol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine-retinol O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidylcholine-retinol O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine-retinol O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables retinoic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of location in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of lipid transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin A metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vitamin A metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin A metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lecithin retinol acyltransferase
    Names
    phosphatidylcholine--retinol O-acyltransferase
    NP_076113.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023624.4NP_076113.1  lecithin retinol acyltransferase

      See identical proteins and their annotated locations for NP_076113.1

      Status: VALIDATED

      Source sequence(s)
      AC158935
      Consensus CDS
      CCDS17430.1
      UniProtKB/Swiss-Prot
      Q9JI60
      UniProtKB/TrEMBL
      B2RUR5
      Related
      ENSMUSP00000029632.7, ENSMUST00000029632.7
      Conserved Domains (1) summary
      pfam04970
      Location:56171
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      82799889..82811281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)