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    Ap3s2 adaptor-related protein complex 3, sigma 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ap3s2provided by MGI
    Official Full Name
    adaptor-related protein complex 3, sigma 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1337060
    See related
    Ensembl:ENSMUSG00000063801 AllianceGenome:MGI:1337060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [s]3B
    Summary
    Involved in anterograde synaptic vesicle transport. Predicted to be located in trans-Golgi network. Predicted to be part of AP-3 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AP3S2 (adaptor related protein complex 3 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.2), CNS E14 (RPKM 15.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ap3s2 in Genome Data Viewer
    Location:
    7 D2; 7 45.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79525073..79570388, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79875325..79920640, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 2 Neighboring gene alanyl aminopeptidase, membrane Neighboring gene STARR-seq mESC enhancer starr_19292 Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor Neighboring gene predicted gene, 31966

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of AP-3 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of AP-3 adaptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-3 complex subunit sigma-2
    Names
    AP-3 complex sigma-3B subunit
    AP-3 complex subunit sigma-3B
    adapter-related protein complex 3 sigma-2 subunit
    adapter-related protein complex 3 subunit sigma-2
    adaptor-related protein complex 3 subunit sigma-2
    adaptor-related protein complex AP-3, sigma 2 subunit
    sigma 3B
    sigma-3B-adaptin
    sigma-adaptin 3b
    sigma3B-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009682.3NP_033812.3  AP-3 complex subunit sigma-2

      See identical proteins and their annotated locations for NP_033812.3

      Status: VALIDATED

      Source sequence(s)
      AC109221, AK150085, BC060236, BY127127
      Consensus CDS
      CCDS21389.1
      UniProtKB/Swiss-Prot
      Q3UDG7, Q8BSZ2, Q8CAY1
      UniProtKB/TrEMBL
      Q6PAL3
      Related
      ENSMUSP00000075082.7, ENSMUST00000075657.8
      Conserved Domains (1) summary
      cd14834
      Location:1146
      AP3_sigma; AP-3 complex subunit sigma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79525073..79570388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)