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    Lat2 linker for activation of T cells family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 56743, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lat2provided by MGI
    Official Full Name
    linker for activation of T cells family, member 2provided by MGI
    Primary source
    MGI:MGI:1926479
    See related
    Ensembl:ENSMUSG00000040751 AllianceGenome:MGI:1926479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAB; NTAL; WSCR5; Wbscr5; Wbscr15
    Summary
    Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 8.2), mammary gland adult (RPKM 2.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lat2 in Genome Data Viewer
    Location:
    5 G2; 5 74.7 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134628957..134648637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134600103..134619783, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene STARR-positive B cell enhancer ABC_E3628 Neighboring gene replication factor C (activator 1) 2 Neighboring gene STARR-positive B cell enhancer ABC_E8085 Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene LIM domain kinase 1 Neighboring gene predicted gene 10369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    linker for activation of T-cells family member 2
    Names
    Williams-Beuren syndrome chromosome region 5 homolog
    linker for activation of B-cells
    membrane-associated adapter molecule
    non-T cell activation linker
    williams-Beuren syndrome chromosomal region 15 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020044.3NP_064428.1  linker for activation of T-cells family member 2 isoform a

      See identical proteins and their annotated locations for NP_064428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK138953, AK143533
      Consensus CDS
      CCDS39312.1
      UniProtKB/Swiss-Prot
      Q3UYF6, Q9JHL0, Q9JJ29
      Related
      ENSMUSP00000046900.7, ENSMUST00000036362.13
      Conserved Domains (1) summary
      pfam15703
      Location:29197
      LAT2; Linker for activation of T-cells family member 2
    2. NM_022964.4NP_075253.2  linker for activation of T-cells family member 2 isoform b

      See identical proteins and their annotated locations for NP_075253.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK138953, AK143533, AK162321
      Consensus CDS
      CCDS39311.1
      UniProtKB/Swiss-Prot
      Q9JHL0
      Related
      ENSMUSP00000076824.5, ENSMUST00000077636.8
      Conserved Domains (1) summary
      pfam15703
      Location:29185
      LAT2; Linker for activation of T-cells family member 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134628957..134648637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504456.5XP_006504519.1  linker for activation of T-cells family member 2 isoform X5

      Conserved Domains (1) summary
      pfam15703
      Location:43138
      LAT2; Linker for activation of T-cells family member 2
    2. XM_006504455.4XP_006504518.1  linker for activation of T-cells family member 2 isoform X4

      Conserved Domains (1) summary
      pfam15703
      Location:80162
      LAT2; Linker for activation of T-cells family member 2
    3. XM_006504453.4XP_006504516.1  linker for activation of T-cells family member 2 isoform X3

      Conserved Domains (1) summary
      pfam15703
      Location:92174
      LAT2; Linker for activation of T-cells family member 2
    4. XM_006504451.4XP_006504514.1  linker for activation of T-cells family member 2 isoform X1

      See identical proteins and their annotated locations for XP_006504514.1

      UniProtKB/Swiss-Prot
      Q3UYF6, Q9JHL0, Q9JJ29
      Conserved Domains (1) summary
      pfam15703
      Location:29197
      LAT2; Linker for activation of T-cells family member 2
    5. XM_006504452.2XP_006504515.1  linker for activation of T-cells family member 2 isoform X2

      See identical proteins and their annotated locations for XP_006504515.1

      UniProtKB/Swiss-Prot
      Q9JHL0
      Conserved Domains (1) summary
      pfam15703
      Location:29185
      LAT2; Linker for activation of T-cells family member 2
    6. XM_006504450.2XP_006504513.1  linker for activation of T-cells family member 2 isoform X1

      See identical proteins and their annotated locations for XP_006504513.1

      UniProtKB/Swiss-Prot
      Q3UYF6, Q9JHL0, Q9JJ29
      Related
      ENSMUSP00000143977.2, ENSMUST00000200998.4
      Conserved Domains (1) summary
      pfam15703
      Location:29197
      LAT2; Linker for activation of T-cells family member 2