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    Dhrs7b dehydrogenase/reductase 7B [ Mus musculus (house mouse) ]

    Gene ID: 216820, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhrs7bprovided by MGI
    Official Full Name
    dehydrogenase/reductase 7Bprovided by MGI
    Primary source
    MGI:MGI:2384931
    See related
    Ensembl:ENSMUSG00000042569 AllianceGenome:MGI:2384931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PexRAP
    Summary
    Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 20.2), mammary gland adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dhrs7b in Genome Data Viewer
    Location:
    11 B2; 11 37.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60721457..60749249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60830631..60858423)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase 1 (soluble) Neighboring gene STARR-positive B cell enhancer ABC_E6992 Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8411 Neighboring gene transmembrane protein 11 Neighboring gene STARR-positive B cell enhancer ABC_E10679 Neighboring gene STARR-seq mESC enhancer starr_29661 Neighboring gene predicted gene, 26534

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC6908

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 7B
    Names
    dehydrogenase/reductase (SDR family) member 7B
    short-chain dehydrogenase/reductase family 32C member 1
    NP_001165583.1
    NP_663403.1
    XP_006532932.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172112.1NP_001165583.1  dehydrogenase/reductase SDR family member 7B isoform 1

      See identical proteins and their annotated locations for NP_001165583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK139084, AL596215
      UniProtKB/TrEMBL
      Z4YKT6
      Related
      ENSMUSP00000104358.2, ENSMUST00000108718.2
      Conserved Domains (2) summary
      cd05332
      Location:41300
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:45310
      PRK06181; short chain dehydrogenase; Provisional
    2. NM_145428.2NP_663403.1  dehydrogenase/reductase SDR family member 7B isoform 2

      See identical proteins and their annotated locations for NP_663403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AK052209, AK139084, AL596215
      Consensus CDS
      CCDS24800.1
      UniProtKB/Swiss-Prot
      Q3UNS3, Q5NCT5, Q99J47
      UniProtKB/TrEMBL
      I7DM66, Z4YKT6
      Related
      ENSMUSP00000044924.8, ENSMUST00000042281.14
      Conserved Domains (2) summary
      cd05332
      Location:50309
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:52319
      PRK06181; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60721457..60749249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532869.5XP_006532932.1  dehydrogenase/reductase SDR family member 7B isoform X1

      UniProtKB/TrEMBL
      Z4YKT6
      Conserved Domains (1) summary
      cd05332
      Location:48307
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs