U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gpr158 G protein-coupled receptor 158 [ Mus musculus (house mouse) ]

    Gene ID: 241263, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gpr158provided by MGI
    Official Full Name
    G protein-coupled receptor 158provided by MGI
    Primary source
    MGI:MGI:2441697
    See related
    Ensembl:ENSMUSG00000045967 AllianceGenome:MGI:2441697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGlyR; mKIAA1136; 5330427M13Rik
    Summary
    Enables enzyme activator activity and transmembrane signaling receptor activity. Involved in several processes, including cognition; positive regulation of neurotransmitter secretion; and protein localization to plasma membrane. Located in membrane. Is active in postsynaptic density membrane. Is expressed in eye; male reproductive gland or organ; nervous system; and small intestine. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 13.3), cortex adult (RPKM 13.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gpr158 in Genome Data Viewer
    Location:
    2 A3; 2 14.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21372378..21835355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21367567..21830544)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 3 pseudogene Neighboring gene predicted gene, 54105 Neighboring gene STARR-seq mESC enhancer starr_03893 Neighboring gene STARR-seq mESC enhancer starr_03894 Neighboring gene STARR-seq mESC enhancer starr_03895 Neighboring gene STARR-seq mESC enhancer starr_03896 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03897 Neighboring gene STARR-seq mESC enhancer starr_03898 Neighboring gene STARR-seq mESC enhancer starr_03899 Neighboring gene predicted gene, 52587 Neighboring gene STARR-seq mESC enhancer starr_03901 Neighboring gene STARR-seq mESC enhancer starr_03902 Neighboring gene predicted gene, 24886 Neighboring gene predicted gene, 39766 Neighboring gene STARR-seq mESC enhancer starr_03903 Neighboring gene predicted gene, 39767 Neighboring gene STARR-seq mESC enhancer starr_03905 Neighboring gene STARR-seq mESC enhancer starr_03907 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1136

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled glycine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled glycine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    metabotropic glycine receptor
    Names
    probable G-protein coupled receptor 158

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004761.1NP_001004761.1  metabotropic glycine receptor precursor

      See identical proteins and their annotated locations for NP_001004761.1

      Status: VALIDATED

      Source sequence(s)
      AB093287, AK083234
      Consensus CDS
      CCDS15722.1
      UniProtKB/Swiss-Prot
      B1AWY4, Q8C419, Q8CHB0
      Related
      ENSMUSP00000049708.8, ENSMUST00000055946.8
      Conserved Domains (1) summary
      pfam00003
      Location:428667
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      21372378..21835355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175706.3: Suppressed sequence

      Description
      NM_175706.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.