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    Rmdn2 regulator of microtubule dynamics 2 [ Mus musculus (house mouse) ]

    Gene ID: 381110, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rmdn2provided by MGI
    Official Full Name
    regulator of microtubule dynamics 2provided by MGI
    Primary source
    MGI:MGI:2147043
    See related
    Ensembl:ENSMUSG00000036368 AllianceGenome:MGI:2147043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RMD-2; mRMD-2; Fam82a1
    Summary
    Predicted to enable microtubule binding activity. Located in mitochondrion. Is expressed in adrenal gland; anal canal; glans of male genital tubercle; hindgut; and testis. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 4.0), adrenal adult (RPKM 1.2) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rmdn2 in Genome Data Viewer
    Location:
    17 E3; 17 50.3 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79886025..80000630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (79578596..79684976)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10494 Neighboring gene mps one binder kinase activator-like 2B pseudogene Neighboring gene STARR-seq mESC enhancer starr_43284 Neighboring gene STARR-seq mESC enhancer starr_43286 Neighboring gene predicted gene, 33006 Neighboring gene predicted gene, 53962 Neighboring gene Cyp1b1 5' regulatory region Neighboring gene cytochrome P450, family 1, subfamily b, polypeptide 1 Neighboring gene predicted gene, 41624

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Clone Names

    • MGC37733

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    regulator of microtubule dynamics protein 2
    Names
    family with sequence similarity 82, member A1
    microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368309.2NP_001355238.1  regulator of microtubule dynamics protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132612
    2. NM_001368310.1NP_001355239.1  regulator of microtubule dynamics protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132612
    3. NM_001368311.1NP_001355240.1  regulator of microtubule dynamics protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132612
    4. NM_001368312.1NP_001355241.1  regulator of microtubule dynamics protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132612
      Conserved Domains (1) summary
      cl30292
      Location:341410
      PRK15331; type III secretion system translocator chaperone SicA
    5. NM_001368313.2NP_001355242.1  regulator of microtubule dynamics protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC132612
    6. NM_001368314.2NP_001355243.1  regulator of microtubule dynamics protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132612
      Consensus CDS
      CCDS28985.1
      UniProtKB/Swiss-Prot
      A9UN02, Q8BSE0, Q8CIF1
      Related
      ENSMUSP00000153443.2, ENSMUST00000225357.2
    7. NM_001414401.1NP_001401330.1  regulator of microtubule dynamics protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132612
      UniProtKB/Swiss-Prot
      A9UN02, Q8BSE0, Q8CIF1
    8. NM_001414402.1NP_001401331.1  regulator of microtubule dynamics protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC132612
    9. NM_001414403.1NP_001401332.1  regulator of microtubule dynamics protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC132612
    10. NM_001414404.1NP_001401333.1  regulator of microtubule dynamics protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC132612
    11. NM_001414405.1NP_001401334.1  regulator of microtubule dynamics protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC132612
    12. NM_001414406.1NP_001401335.1  regulator of microtubule dynamics protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC132612
    13. NM_001414407.1NP_001401336.1  regulator of microtubule dynamics protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC132612
    14. NM_001414408.1NP_001401337.1  regulator of microtubule dynamics protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132612
    15. NM_201361.3NP_958749.1  regulator of microtubule dynamics protein 2 isoform 1

      See identical proteins and their annotated locations for NP_958749.1

      Status: VALIDATED

      Source sequence(s)
      AC132612
      Consensus CDS
      CCDS28985.1
      UniProtKB/Swiss-Prot
      A9UN02, Q8BSE0, Q8CIF1
      Related
      ENSMUSP00000044543.3, ENSMUST00000040368.3
      Conserved Domains (1) summary
      TIGR02552
      Location:341410
      LcrH_SycD; type III secretion low calcium response chaperone LcrH/SycD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      79886025..80000630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524498.3XP_006524561.1  regulator of microtubule dynamics protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524561.1

      Conserved Domains (1) summary
      sd00006
      Location:608658
      TPR; TPR repeat [structural motif]
    2. XM_006524499.4XP_006524562.1  regulator of microtubule dynamics protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524562.1

      Conserved Domains (1) summary
      sd00006
      Location:608658
      TPR; TPR repeat [structural motif]
    3. XM_006524497.1XP_006524560.1  regulator of microtubule dynamics protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524560.1

      Conserved Domains (1) summary
      sd00006
      Location:608658
      TPR; TPR repeat [structural motif]
    4. XM_006524507.1XP_006524570.1  regulator of microtubule dynamics protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524570.1

    5. XM_006524502.4XP_006524565.1  regulator of microtubule dynamics protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006524565.1

    6. XM_006524501.4XP_006524564.1  regulator of microtubule dynamics protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006524564.1

    7. XM_006524503.5XP_006524566.1  regulator of microtubule dynamics protein 2 isoform X3

    8. XM_006524496.5XP_006524559.1  regulator of microtubule dynamics protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006524559.1

      Conserved Domains (1) summary
      sd00006
      Location:608658
      TPR; TPR repeat [structural motif]
    9. XM_036160671.1XP_036016564.1  regulator of microtubule dynamics protein 2 isoform X1

      Conserved Domains (1) summary
      sd00006
      Location:608658
      TPR; TPR repeat [structural motif]
    10. XM_036160673.1XP_036016566.1  regulator of microtubule dynamics protein 2 isoform X4

      Conserved Domains (1) summary
      cl30292
      Location:341410
      PRK15331; type III secretion system translocator chaperone SicA
    11. XM_030249874.1XP_030105734.1  regulator of microtubule dynamics protein 2 isoform X6

      Conserved Domains (1) summary
      cl30292
      Location:145214
      PRK15331; type III secretion system translocator chaperone SicA