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    Rprd2 regulation of nuclear pre-mRNA domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 75137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rprd2provided by MGI
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 2provided by MGI
    Primary source
    MGI:MGI:1922387
    See related
    Ensembl:ENSMUSG00000028106 AllianceGenome:MGI:1922387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0460; 2810036A19Rik; 4930535B03Rik; 6720469I21Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of transcription preinitiation complex. Is expressed in several structures, including blastocyst; cerebral cortex; early embryo; and extraembryonic component. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.3), limb E14.5 (RPKM 5.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rprd2 in Genome Data Viewer
    Location:
    3 F2.1; 3 41.0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95667183..95727034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95759871..95819744, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene predicted gene, 26361 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene STARR-seq mESC enhancer starr_08396 Neighboring gene predicted gene, 29948 Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene mitochondrial ribosomal protein S21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081293.2NP_001074762.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC093317, BC067054
      Consensus CDS
      CCDS38549.1
      UniProtKB/Swiss-Prot
      Q3U3L8, Q6NXI6, Q6ZQA7
      UniProtKB/TrEMBL
      A0A0G2JFW6
      Related
      ENSMUSP00000088297.4, ENSMUST00000090791.8
      Conserved Domains (1) summary
      smart00582
      Location:27145
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    2. NM_001368178.2NP_001355107.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093317, FQ790371
      UniProtKB/TrEMBL
      A0A0G2JFW6
    3. NM_001368179.1NP_001355108.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC093317, FQ790371
      UniProtKB/TrEMBL
      A0A0G2JFW6
      Related
      ENSMUSP00000143333.2, ENSMUST00000200164.5
    4. NM_001368180.1NP_001355109.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093317
    5. NM_001368181.1NP_001355110.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093317
    6. NM_028328.2NP_082604.2  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093317
      Consensus CDS
      CCDS89669.1
      UniProtKB/TrEMBL
      A0A0G2JFN1
      Related
      ENSMUSP00000143240.2, ENSMUST00000197449.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95667183..95727034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252863.2XP_030108723.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JFW6
      Conserved Domains (3) summary
      PRK03918
      Location:142318
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:319645
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd17001
      Location:27146
      CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
    2. XM_011240267.4XP_011238569.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam05109
      Location:293619
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd17001
      Location:27145
      CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029180.1: Suppressed sequence

      Description
      NM_029180.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.