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    Fzd1 frizzled class receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14362, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd1provided by MGI
    Official Full Name
    frizzled class receptor 1provided by MGI
    Primary source
    MGI:MGI:1196625
    See related
    Ensembl:ENSMUSG00000044674 AllianceGenome:MGI:1196625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fz1; FZ-1
    Summary
    Enables Wnt-protein binding activity. Involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway and regulation of presynapse assembly. Acts upstream of or within several processes, including hard palate development; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human FZD1 (frizzled class receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Fzd1 in Genome Data Viewer
    Location:
    5 A1; 5 2.61 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4803839..4808216, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4753839..4758216, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12326 Neighboring gene STARR-seq mESC enhancer starr_12327 Neighboring gene STARR-seq mESC enhancer starr_12328 Neighboring gene STARR-seq mESC enhancer starr_12329 Neighboring gene STARR-seq mESC enhancer starr_12330 Neighboring gene predicted gene, 40261 Neighboring gene STARR-seq mESC enhancer starr_12331 Neighboring gene STARR-seq mESC enhancer starr_12332 Neighboring gene STARR-seq mESC enhancer starr_12333 Neighboring gene STARR-seq mESC enhancer starr_12334 Neighboring gene STARR-seq mESC enhancer starr_12336 Neighboring gene predicted gene, 54299 Neighboring gene STARR-seq mESC enhancer starr_12337 Neighboring gene cyclin dependent kinase 14 Neighboring gene STARR-seq mESC enhancer starr_12338 Neighboring gene VISTA enhancer mm49 Neighboring gene predicted gene, 22897 Neighboring gene predicted gene, 54300

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte-dopaminergic neuron signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autocrine signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autocrine signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within endothelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within hard palate development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within membranous septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within muscular septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mesenchymal stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mesenchymal stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    frizzled-1
    Names
    frizzled homolog 1
    mFz1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021457.3NP_067432.2  frizzled-1 precursor

      See identical proteins and their annotated locations for NP_067432.2

      Status: VALIDATED

      Source sequence(s)
      AK143101, BC053010, BE948559
      Consensus CDS
      CCDS19072.1
      UniProtKB/Swiss-Prot
      O08974, O70421, Q7TS82
      Related
      ENSMUSP00000058629.5, ENSMUST00000054294.7
      Conserved Domains (2) summary
      cd07465
      Location:107233
      CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
      cd15247
      Location:294641
      7tmF_FZD1; class F mammalian frizzled subfamily 1, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      4803839..4808216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)